HKT22_ORYSI
ID HKT22_ORYSI Reviewed; 530 AA.
AC Q93XI5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Cation transporter HKT2;2 {ECO:0000303|PubMed:16809061};
DE Short=OsHKT2;2 {ECO:0000303|PubMed:16809061};
DE AltName: Full=Cation transporter HKT2 {ECO:0000303|PubMed:11489190};
DE Short=OsHKT2 {ECO:0000303|PubMed:11489190};
DE AltName: Full=Po-OsHKT2 {ECO:0000303|PubMed:11489190};
GN Name=HKT2;2 {ECO:0000303|PubMed:11489190};
GN Synonyms=HKT2 {ECO:0000303|PubMed:11489190};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=cv. Pokkali; TISSUE=Seedling root;
RX PubMed=11489190; DOI=10.1046/j.1365-313x.2001.01077.x;
RA Horie T., Yoshida K., Nakayama H., Yamada K., Oiki S., Shinmyo A.;
RT "Two types of HKT transporters with different properties of Na+ and K+
RT transport in Oryza sativa.";
RL Plant J. 27:129-138(2001).
RN [2]
RP FUNCTION, DOMAIN, AND MUTAGENESIS OF GLY-88.
RX PubMed=11959905; DOI=10.1073/pnas.082123799;
RA Maeser P., Hosoo Y., Goshima S., Horie T., Eckelman B., Yamada K.,
RA Yoshida K., Bakker E.P., Shinmyo A., Oiki S., Schroeder J.I., Uozumi N.;
RT "Glycine residues in potassium channel-like selectivity filters determine
RT potassium selectivity in four-loop-per-subunit HKT transporters from
RT plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:6428-6433(2002).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16809061; DOI=10.1016/j.tplants.2006.06.001;
RA Platten J.D., Cotsaftis O., Berthomieu P., Bohnert H., Davenport R.J.,
RA Fairbairn D.J., Horie T., Leigh R.A., Lin H.X., Luan S., Maeser P.,
RA Pantoja O., Rodriguez-Navarro A., Schachtman D.P., Schroeder J.I.,
RA Sentenac H., Uozumi N., Very A.A., Zhu J.K., Dennis E.S., Tester M.;
RT "Nomenclature for HKT transporters, key determinants of plant salinity
RT tolerance.";
RL Trends Plant Sci. 11:372-374(2006).
CC -!- FUNCTION: Seems to be involved in regulation of potassium-sodium
CC homeostasis (PubMed:11489190, PubMed:11959905). Seems to act as a
CC potassium-sodium cotransporter, which mediates increased potassium
CC uptake under external sodium accumulation and contributes to salt-
CC tolerance in cultivar indica Pokkali (PubMed:11489190,
CC PubMed:11959905). {ECO:0000269|PubMed:11489190,
CC ECO:0000269|PubMed:11959905}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Induced by potassium starvation in roots. Down-regulated by
CC sodium. {ECO:0000269|PubMed:11489190}.
CC -!- DOMAIN: HKT transporters are proposed to contain 4 pore-forming regions
CC enclosed by transmembrane segments with each containing a potassium
CC channel-like selectivity filter motif. {ECO:0000269|PubMed:11959905}.
CC -!- SIMILARITY: Belongs to the TrkH potassium transport family. HKT (TC
CC 2.A.38.3) subfamily. {ECO:0000305}.
CC -!- CAUTION: HKT2 is found in salt-tolerant cultivar indica Pokkali. It
CC does not exist in cultivar indica 93-11 or japonica Nipponbare.
CC {ECO:0000305}.
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DR EMBL; AB061313; BAB61791.1; -; mRNA.
DR AlphaFoldDB; Q93XI5; -.
DR SMR; Q93XI5; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003445; Cat_transpt.
DR Pfam; PF02386; TrkH; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Potassium; Potassium transport; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..530
FT /note="Cation transporter HKT2;2"
FT /id="PRO_0000070467"
FT TOPO_DOM 1..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 393..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 515..530
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MUTAGEN 88
FT /note="G->S: Loss of selectivity for potassium uptake."
FT /evidence="ECO:0000269|PubMed:11959905"
SQ SEQUENCE 530 AA; 59152 MW; 73087CF493AD3360 CRC64;
MTSIYQEFIH TKCQSFRSIG RYVLHSIVLI YRFVSLHVHP FWIQLSYFLL ISILGSVLLM
FLKPSSPEFK PGYIDMLFLS TSAMTVSGLS TIEMEVLSSS QIVVLTLLML VGGEVFVSFL
GLMLRLKHKH NPEFSGDRVS SVPIELDTIE PTRTVMSSEE LQIEAAAPDV PSSTIKDLKR
SKRLRWFLGF VVFSYFVVIH VVGFLLVLWY ISRVSSAKAP LKKKGINIAL FSFSVTVSSF
ANGGLVPTNE NMAIFSKNPG LLLLFIGQIL AGNTLYPLFL RILIWFLGKV TKLKDLKLMI
KNSDELQYDY LLPKLPTAFL ASTVIGLMAS LVTLFGSVDW NSSVFDGLSS YQKIINALFM
AVNARHSGEN SIDCSLIAPA VLVLFIILMY LPPSTTFALS NGDEKTANKK AKRKLGLVVR
NLAFSQLACN AVFVIVALIT ERSRLRNDPL NFSALNMIFE VISAYGNVGL TTGYSCSRLQ
KLHPGSICQD KPYSLSGWWS DEGKLLLVSV MLYGRLKAFT KGTGEYWRLW
