HLAH_HUMAN
ID HLAH_HUMAN Reviewed; 362 AA.
AC P01893;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Putative HLA class I histocompatibility antigen, alpha chain H;
DE AltName: Full=HLA-12.4;
DE AltName: Full=HLA-AR;
DE AltName: Full=MHC class I antigen H;
DE Flags: Precursor;
GN Name=HLA-H; Synonyms=HLAH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6461010; DOI=10.1073/pnas.79.3.893;
RA Malissen M., Malissen B., Jordan B.R.;
RT "Exon/intron organization and complete nucleotide sequence of an HLA
RT gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:893-897(1982).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- INTERACTION:
CC P01893; P11142: HSPA8; NbExp=2; IntAct=EBI-3197925, EBI-351896;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA36218.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; J00191; AAA36218.1; ALT_INIT; Genomic_DNA.
DR PIR; A02189; HLHU12.
DR AlphaFoldDB; P01893; -.
DR SMR; P01893; -.
DR IntAct; P01893; 8.
DR MINT; P01893; -.
DR GlyGen; P01893; 1 site.
DR iPTMnet; P01893; -.
DR PhosphoSitePlus; P01893; -.
DR SwissPalm; P01893; -.
DR BioMuta; HGNC:4965; -.
DR EPD; P01893; -.
DR jPOST; P01893; -.
DR MassIVE; P01893; -.
DR MaxQB; P01893; -.
DR PeptideAtlas; P01893; -.
DR PRIDE; P01893; -.
DR ProteomicsDB; 51507; -.
DR GeneCards; HLA-H; -.
DR HGNC; HGNC:4965; HLA-H.
DR MIM; 142800; gene.
DR neXtProt; NX_P01893; -.
DR InParanoid; P01893; -.
DR PhylomeDB; P01893; -.
DR PathwayCommons; P01893; -.
DR Reactome; R-HSA-1236974; ER-Phagosome pathway.
DR Reactome; R-HSA-1236977; Endosomal/Vacuolar pathway.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-877300; Interferon gamma signaling.
DR Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR Reactome; R-HSA-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR SignaLink; P01893; -.
DR ChiTaRS; HLA-H; human.
DR Pharos; P01893; Tbio.
DR PRO; PR:P01893; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P01893; protein.
DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR GO; GO:0009986; C:cell surface; IMP:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; TAS:Reactome.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0055038; C:recycling endosome membrane; TAS:Reactome.
DR GO; GO:0030881; F:beta-2-microglobulin binding; IMP:UniProtKB.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR InterPro; IPR010579; MHC_I_a_C.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..362
FT /note="Putative HLA class I histocompatibility antigen,
FT alpha chain H"
FT /id="PRO_0000018888"
FT TOPO_DOM 25..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 209..297
FT /note="Ig-like C1-type"
FT REGION 25..114
FT /note="Alpha-1"
FT REGION 115..206
FT /note="Alpha-2"
FT REGION 207..298
FT /note="Alpha-3"
FT REGION 299..308
FT /note="Connecting peptide"
FT REGION 337..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT DISULFID 227..283
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 362 AA; 40892 MW; 8ADFD2388FEC4645 CRC64;
MVLMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF
DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ
VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR
RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL
TA
