3SOFB_NAJHH
ID 3SOFB_NAJHH Reviewed; 62 AA.
AC P62394; P01472;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Cytotoxin 11;
DE AltName: Full=Toxin CM-12 {ECO:0000303|PubMed:710433};
OS Naja haje haje (Egyptian cobra).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=8642;
RN [1]
RP PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=710433; DOI=10.1111/j.1432-1033.1978.tb12612.x;
RA Joubert F.J., Taljaard N.;
RT "Naja haje haje (Egyptian cobra) venom. Some properties and the complete
RT primary structure of three toxins (CM-2, CM-11 and CM-12).";
RL Eur. J. Biochem. 90:359-367(1978).
CC -!- FUNCTION: Has low cytotoxic activity. {ECO:0000250|UniProtKB:P14541}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:710433}. Target cell
CC membrane {ECO:0000250|UniProtKB:P62375}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- TOXIC DOSE: LD(50) is 25.2 mg/kg by intravenous injection.
CC {ECO:0000269|PubMed:710433}.
CC -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC residue stands at position 31 (Pro-31 in standard classification).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P62394; -.
DR SMR; P62394; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003572; Cytotoxin_Cobra.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR InterPro; IPR035076; Toxin/TOLIP.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR PRINTS; PR00282; CYTOTOXIN.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Membrane; Secreted;
KW Target cell membrane; Target membrane; Toxin.
FT CHAIN 1..62
FT /note="Cytotoxin 11"
FT /evidence="ECO:0000269|PubMed:710433"
FT /id="PRO_0000093497"
FT DISULFID 3..22
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 15..40
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 44..55
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 56..61
FT /evidence="ECO:0000250|UniProtKB:P60301"
SQ SEQUENCE 62 AA; 6842 MW; 7BBADD9BD39C0264 CRC64;
LKCHNTQLPF IYKTCPEGKN LCFKTTLKKL PLKIPIKRGC AATCPKSSAL LKVVCCSTDK
CN