ID   HLD_STAA8               Reviewed;          26 AA.
AC   Q2FWM8; P01506; P0A0M3;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 3.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Delta-hemolysin;
DE            Short=Delta-lysin;
DE   AltName: Full=Delta-toxin;
GN   Name=hld; OrderedLocusNames=SAOUHSC_02260;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2622452; DOI=10.1007/bf00259623;
RA   Janzon L., Loefdahl S., Arvidson S.;
RT   "Identification and nucleotide sequence of the delta-lysin gene, hld,
RT   adjacent to the accessory gene regulator (agr) of Staphylococcus aureus.";
RL   Mol. Gen. Genet. 219:480-485(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bischoff M.;
RT   "DNA for hld, agrB, and agrD genes of Staphylococcus aureus strain
RT   RN4220.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Lyses erythrocytes and many other mammalian cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}. Note=In infected cells, it is found in the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the delta-lysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF43204.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=ABD31299.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF230358; AAF43204.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP000253; ABD31299.1; ALT_INIT; Genomic_DNA.
DR   PIR; A01767; LESAD.
DR   RefSeq; YP_500742.1; NC_007795.1.
DR   AlphaFoldDB; Q2FWM8; -.
DR   BMRB; Q2FWM8; -.
DR   SMR; Q2FWM8; -.
DR   STRING; 1280.SAXN108_2128; -.
DR   EnsemblBacteria; ABD31299; ABD31299; SAOUHSC_02260.
DR   GeneID; 3919680; -.
DR   KEGG; sao:SAOUHSC_02260; -.
DR   PATRIC; fig|93061.5.peg.2053; -.
DR   HOGENOM; CLU_3222291_0_0_9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR008034; Delta_lysin.
DR   Pfam; PF05372; Delta_lysin; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Formylation; Hemolysis; Host cell membrane; Host membrane;
KW   Membrane; Reference proteome; Secreted; Toxin; Transmembrane; Virulence.
FT   PEPTIDE         1..26
FT                   /note="Delta-hemolysin"
FT                   /id="PRO_0000249337"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2979 MW;  854433C5EFE4DFD2 CRC64;
     MAQDIISTIG DLVKWIIDTV NKFTKK