ID   HLD_STAAM               Reviewed;          26 AA.
AC   P0A0M1; P01506;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Delta-hemolysin;
DE            Short=Delta-lysin;
DE   AltName: Full=Delta-toxin;
GN   Name=hld; OrderedLocusNames=SAV2035;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Lyses erythrocytes and many other mammalian cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}. Note=In infected cells, it is found in the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the delta-lysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB58197.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB58197.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P0A0M1; -.
DR   BMRB; P0A0M1; -.
DR   SMR; P0A0M1; -.
DR   PaxDb; P0A0M1; -.
DR   EnsemblBacteria; BAB58197; BAB58197; SAV2035.
DR   KEGG; sav:SAV2035; -.
DR   HOGENOM; CLU_3222291_0_0_9; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR008034; Delta_lysin.
DR   Pfam; PF05372; Delta_lysin; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Formylation; Hemolysis; Host cell membrane; Host membrane;
KW   Membrane; Secreted; Toxin; Transmembrane; Virulence.
FT   PEPTIDE         1..26
FT                   /note="Delta-hemolysin"
FT                   /id="PRO_0000035638"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2979 MW;  854433C5EFE4DFD2 CRC64;
     MAQDIISTIG DLVKWIIDTV NKFTKK