ID   HLD_STAAN               Reviewed;          26 AA.
AC   P0A0M2; P01506;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Delta-hemolysin;
DE            Short=Delta-lysin;
DE   AltName: Full=Delta-toxin;
GN   Name=hld; OrderedLocusNames=SA1841.1; ORFNames=SAS065;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Lyses erythrocytes and many other mammalian cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}. Note=In infected cells, it is found in the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the delta-lysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB43122.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000018; BAB43122.1; ALT_INIT; Genomic_DNA.
DR   PIR; A89995; A89995.
DR   AlphaFoldDB; P0A0M2; -.
DR   BMRB; P0A0M2; -.
DR   SMR; P0A0M2; -.
DR   EnsemblBacteria; BAB43122; BAB43122; BAB43122.
DR   KEGG; sau:SAS065; -.
DR   HOGENOM; CLU_3222291_0_0_9; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR008034; Delta_lysin.
DR   Pfam; PF05372; Delta_lysin; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Formylation; Hemolysis; Host cell membrane; Host membrane;
KW   Membrane; Secreted; Toxin; Transmembrane; Virulence.
FT   PEPTIDE         1..26
FT                   /note="Delta-hemolysin"
FT                   /id="PRO_0000035640"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2979 MW;  854433C5EFE4DFD2 CRC64;
     MAQDIISTIG DLVKWIIDTV NKFTKK