ID   HLD_STAAR               Reviewed;          26 AA.
AC   Q6GF37;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Delta-hemolysin;
DE            Short=Delta-lysin;
DE   AltName: Full=Delta-toxin;
GN   Name=hld; OrderedLocusNames=SAR2122;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Lyses erythrocytes and many other mammalian cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}. Note=In infected cells, it is found in the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the delta-lysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG41103.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX571856; CAG41103.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q6GF37; -.
DR   SMR; Q6GF37; -.
DR   KEGG; sar:SAR2122; -.
DR   HOGENOM; CLU_3222291_0_0_9; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR008034; Delta_lysin.
DR   Pfam; PF05372; Delta_lysin; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Formylation; Hemolysis; Host cell membrane; Host membrane;
KW   Membrane; Secreted; Toxin; Transmembrane; Virulence.
FT   PEPTIDE         1..26
FT                   /note="Delta-hemolysin"
FT                   /id="PRO_0000035642"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2979 MW;  854433C5EFE4DFD2 CRC64;
     MAQDIISTIG DLVKWIIDTV NKFTKK