HLD_STAAU
ID HLD_STAAU Reviewed; 26 AA.
AC P0C1V1; P01506; P0A0M3;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Delta-hemolysin;
DE Short=Delta-lysin;
DE AltName: Full=Delta-toxin;
GN Name=hld;
OS Staphylococcus aureus.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate GAL;
RX PubMed=7565609; DOI=10.1007/bf02191645;
RA Novick R.P., Projan S.J., Kornblum J., Ross H.F., Ji G., Kreiswirth B.,
RA Vandenesch F., Moghazeh S.;
RT "The agr P2 operon: an autocatalytic sensory transduction system in
RT Staphylococcus aureus.";
RL Mol. Gen. Genet. 248:446-458(1995).
RN [2]
RP PROTEIN SEQUENCE, AND FORMYLATION AT MET-1.
RC STRAIN=186X;
RX PubMed=7398877; DOI=10.1016/0014-5793(80)81170-7;
RA Fitton J.E., Dell A., Shaw W.V.;
RT "The amino acid sequence of the delta haemolysin of Staphylococcus
RT aureus.";
RL FEBS Lett. 115:209-212(1980).
RN [3]
RP PROTEIN SEQUENCE.
RC STRAIN=Canine variant;
RA Fitton J.E., Hunt D.F., Marasco J., Shabanowitz J., Winston S., Dell A.;
RT "The amino acid sequence of delta haemolysin purified from a canine isolate
RT of S. aureus.";
RL FEBS Lett. 169:25-29(1984).
RN [4]
RP 3D-STRUCTURE MODELING.
RX PubMed=2281085; DOI=10.1002/prot.340080304;
RA Raghunathan G., Seetharamulu P., Brooks B.R., Guy H.R.;
RT "Models of delta-hemolysin membrane channels and crystal structures.";
RL Proteins 8:213-225(1990).
CC -!- FUNCTION: Lyses erythrocytes and many other mammalian cells.
CC -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane. Note=In infected
CC cells, it is found in the membrane.
CC -!- SIMILARITY: Belongs to the delta-lysin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA36780.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X52543; CAA36780.1; ALT_INIT; Genomic_DNA.
DR PIR; A01767; LESAD.
DR RefSeq; WP_000046022.1; NZ_WIPO01000006.1.
DR PDB; 1DTC; NMR; -; A=1-26.
DR PDB; 2DTB; NMR; -; A=1-26.
DR PDB; 2KAM; NMR; -; A=1-26.
DR PDBsum; 1DTC; -.
DR PDBsum; 2DTB; -.
DR PDBsum; 2KAM; -.
DR AlphaFoldDB; P0C1V1; -.
DR BMRB; P0C1V1; -.
DR SMR; P0C1V1; -.
DR DrugBank; DB04464; N-Formylmethionine.
DR TCDB; 1.C.122.1.1; the pore-forming delta-hemolysin (hld) family.
DR EvolutionaryTrace; P0C1V1; -.
DR PRO; PR:P0C1V1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR InterPro; IPR008034; Delta_lysin.
DR Pfam; PF05372; Delta_lysin; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytolysis; Direct protein sequencing; Formylation; Hemolysis;
KW Host cell membrane; Host membrane; Membrane; Secreted; Toxin;
KW Transmembrane; Virulence.
FT PEPTIDE 1..26
FT /note="Delta-hemolysin"
FT /id="PRO_0000035648"
FT MOD_RES 1
FT /note="N-formylmethionine"
FT /evidence="ECO:0000269|PubMed:7398877"
FT VARIANT 3
FT /note="Q -> A (in strain: canine)"
FT VARIANT 10..12
FT /note="GDL -> VEF (in strain: canine)"
FT VARIANT 15
FT /note="W -> L (in strain: canine)"
FT VARIANT 17..18
FT /note="ID -> AE (in strain: canine)"
FT VARIANT 21
FT /note="N -> E (in strain: canine)"
FT VARIANT 24
FT /note="T -> I (in strain: canine)"
FT HELIX 2..22
FT /evidence="ECO:0007829|PDB:1DTC"
SQ SEQUENCE 26 AA; 2979 MW; 854433C5EFE4DFD2 CRC64;
MAQDIISTIG DLVKWIIDTV NKFTKK
