ID   HLGB_STAAR              Reviewed;         325 AA.
AC   Q6GE12;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Gamma-hemolysin component B;
DE   AltName: Full=H-gamma-1;
DE   AltName: Full=H-gamma-I;
DE   Flags: Precursor;
GN   Name=hlgB; OrderedLocusNames=SAR2511;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Toxin that seems to act by forming pores in the membrane of
CC       the cell. Has a hemolytic and a leucotoxic activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Toxicity requires sequential binding and synergistic
CC       association of a class S and a class F component which form
CC       heterooligomeric complexes. HlgB (class F) associates with either HlgA
CC       thus forming an AB toxin or with HlgC thus forming a CB toxin (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41491.1; -; Genomic_DNA.
DR   RefSeq; WP_001056917.1; NC_002952.2.
DR   AlphaFoldDB; Q6GE12; -.
DR   SMR; Q6GE12; -.
DR   KEGG; sar:SAR2511; -.
DR   HOGENOM; CLU_055394_0_1_9; -.
DR   OMA; QNAKTHT; -.
DR   OrthoDB; 747039at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Hemolysis; Signal; Toxin; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..325
FT                   /note="Gamma-hemolysin component B"
FT                   /id="PRO_0000045218"
SQ   SEQUENCE   325 AA;  36812 MW;  38A0066D8DBD8935 CRC64;
     MNMNKLVKSS VATSMALLLL SNTANAEGKI TPVSVKKVDD KVTLYKTTAT ADSDKFKISQ
     ILTFNFIKDK SYDKDTLVLK AAGNINSGYE RPNPKDYDFS KIYWGAKYNV SISSQSNDSV
     NVVDYAPKNQ NEEFQVQNTL GYTFGGDISI SNGLSGGLNG NTAFSETINY KQESYRTTLS
     RNTNYKNVGW GVEAHKIMNN GWGPYGRDSF HPTYGNELFL AGRQSSAYAG QNFIAQHQMP
     LLSRSNFNPE FLSVLSHRQD GAKKSKITVT YQREMDLYQI RWNGFYWAGA NYKNFKTRTF
     KSTYEIDWEN HKVKLLDTKE TENNK