HLGB_STAAU
ID HLGB_STAAU Reviewed; 325 AA.
AC P0A077; Q07226;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Gamma-hemolysin component B;
DE AltName: Full=H-gamma-1;
DE AltName: Full=H-gamma-I;
DE Flags: Precursor;
GN Name=hlgB;
OS Staphylococcus aureus.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8423103; DOI=10.1128/iai.61.2.768-771.1993;
RA Cooney J.C., Kienle Z., Foster T.J., O'Toole P.W.;
RT "The gamma-hemolysin locus of Staphylococcus aureus comprises three linked
RT genes, two of which are identical to the genes for the F and S components
RT of leukocidin.";
RL Infect. Immun. 61:768-771(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3075655; DOI=10.1099/00221287-134-8-2179;
RA Cooney J.C., Mulvey M., Arbuthnott J., Foster T.;
RT "Molecular cloning and genetic analysis of the determinant for gamma-lysin,
RT a two-component toxin of Staphylococcus aureus.";
RL J. Gen. Microbiol. 134:2179-2188(1988).
CC -!- FUNCTION: Toxin that seems to act by forming pores in the membrane of
CC the cell. Has a hemolytic and a leucotoxic activity.
CC -!- SUBUNIT: Toxicity requires sequential binding and synergistic
CC association of a class S and a class F component which form
CC heterooligomeric complexes. HlgB (class F) associates with either HlgA
CC thus forming an AB toxin or with HlgC thus forming a CB toxin.
CC -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR EMBL; L01055; AAA26639.1; -; Genomic_DNA.
DR PIR; B49238; B49238.
DR RefSeq; WP_000783428.1; NZ_WYDB01000001.1.
DR PDB; 1LKF; X-ray; 1.90 A; A=27-325.
DR PDB; 2LKF; X-ray; 2.50 A; A=27-325.
DR PDB; 2QK7; X-ray; 2.40 A; B=27-325.
DR PDB; 3LKF; X-ray; 1.90 A; A=27-325.
DR PDBsum; 1LKF; -.
DR PDBsum; 2LKF; -.
DR PDBsum; 2QK7; -.
DR PDBsum; 3LKF; -.
DR AlphaFoldDB; P0A077; -.
DR SMR; P0A077; -.
DR TCDB; 1.C.3.4.2; the Alpha-hemolysin channel-forming toxin (Alphahl) family.
DR ABCD; P0A077; 7 sequenced antibodies.
DR OMA; QNAKTHT; -.
DR EvolutionaryTrace; P0A077; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR InterPro; IPR003963; Bi-component_toxin_staph.
DR InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR Pfam; PF07968; Leukocidin; 1.
DR PRINTS; PR01468; BICOMPNTOXIN.
DR SUPFAM; SSF56959; SSF56959; 1.
DR TIGRFAMs; TIGR01002; hlyII; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytolysis; Hemolysis; Signal; Toxin; Virulence.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..325
FT /note="Gamma-hemolysin component B"
FT /id="PRO_0000018424"
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 34..37
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 39..53
FT /evidence="ECO:0007829|PDB:1LKF"
FT TURN 54..57
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 58..69
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 72..86
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 98..114
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 120..127
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 134..142
FT /evidence="ECO:0007829|PDB:1LKF"
FT TURN 144..146
FT /evidence="ECO:0007829|PDB:3LKF"
FT STRAND 148..152
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 164..171
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 175..179
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 187..194
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 199..202
FT /evidence="ECO:0007829|PDB:1LKF"
FT TURN 212..214
FT /evidence="ECO:0007829|PDB:1LKF"
FT HELIX 229..231
FT /evidence="ECO:0007829|PDB:1LKF"
FT HELIX 236..238
FT /evidence="ECO:0007829|PDB:1LKF"
FT HELIX 241..244
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 251..257
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 259..261
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 263..282
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 287..307
FT /evidence="ECO:0007829|PDB:1LKF"
FT TURN 308..311
FT /evidence="ECO:0007829|PDB:1LKF"
FT STRAND 312..324
FT /evidence="ECO:0007829|PDB:1LKF"
SQ SEQUENCE 325 AA; 36711 MW; 082999EB9339B6A0 CRC64;
MKMNKLVKSS VATSMALLLL SGTANAEGKI TPVSVKKVDD KVTLYKTTAT ADSDKFKISQ
ILTFNFIKDK SYDKDTLVLK ATGNINSGFV KPNPNDYDFS KLYWGAKYNV SISSQSNDSV
NVVDYAPKNQ NEEFQVQNTL GYTFGGDISI SNGLSGGLNG NTAFSETINY KQESYRTTLS
RNTNYKNVGW GVEAHKIMNN GWGPYGRDSF HPTYGNELFL AGRQSSAYAG QNFIAQHQMP
LLSRSNFNPE FLSVLSHRQD GAKKSKITVT YQREMDLYQI RWNGFYWAGA NYKNFKTRTF
KSTYEIDWEN HKVKLLDTKE TENNK
