HLGC_STAAM
ID HLGC_STAAM Reviewed; 315 AA.
AC Q99RL1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Gamma-hemolysin component C;
DE Flags: Precursor;
GN Name=hlgC; OrderedLocusNames=SAV2420;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Toxin that seems to act by forming pores in the membrane of
CC the cell. Has a hemolytic and a leucotoxic activity (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Toxicity requires sequential binding and synergistic
CC association of a class S and a class F component which form
CC heterooligomeric complexes. HlgC (class S) associates with HlgB (class
CC F) thus forming an CB toxin (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR EMBL; BA000017; BAB58582.1; -; Genomic_DNA.
DR RefSeq; WP_000916704.1; NC_002758.2.
DR PDB; 4P1X; X-ray; 2.40 A; B/D/F/H=30-315.
DR PDBsum; 4P1X; -.
DR AlphaFoldDB; Q99RL1; -.
DR SMR; Q99RL1; -.
DR PaxDb; Q99RL1; -.
DR EnsemblBacteria; BAB58582; BAB58582; SAV2420.
DR KEGG; sav:SAV2420; -.
DR HOGENOM; CLU_075311_0_0_9; -.
DR PhylomeDB; Q99RL1; -.
DR BioCyc; SAUR158878:SAV_RS13190-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR InterPro; IPR003963; Bi-component_toxin_staph.
DR InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR Pfam; PF07968; Leukocidin; 1.
DR PRINTS; PR01468; BICOMPNTOXIN.
DR SUPFAM; SSF56959; SSF56959; 1.
DR TIGRFAMs; TIGR01002; hlyII; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytolysis; Hemolysis; Signal; Toxin; Virulence.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..315
FT /note="Gamma-hemolysin component C"
FT /id="PRO_0000045221"
FT STRAND 42..53
FT /evidence="ECO:0007829|PDB:4P1X"
FT TURN 54..57
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 58..69
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 72..86
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 90..93
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 98..115
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 120..127
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 133..144
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 160..181
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 184..191
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 193..196
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 199..202
FT /evidence="ECO:0007829|PDB:4P1X"
FT TURN 206..209
FT /evidence="ECO:0007829|PDB:4P1X"
FT HELIX 219..222
FT /evidence="ECO:0007829|PDB:4P1X"
FT HELIX 226..228
FT /evidence="ECO:0007829|PDB:4P1X"
FT HELIX 231..234
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 241..247
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 253..273
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 281..303
FT /evidence="ECO:0007829|PDB:4P1X"
FT TURN 304..306
FT /evidence="ECO:0007829|PDB:4P1X"
FT STRAND 309..314
FT /evidence="ECO:0007829|PDB:4P1X"
SQ SEQUENCE 315 AA; 35584 MW; DF459166DF16266F CRC64;
MLKNKILATT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED KTSNKWGVTQ
NIQFDFVKDK KYNKDALILK MQGFISSRTT YYNYKKTNHV KAMRWPFQYN IGLKTNDKYV
SLINYLPKNK IESTNVSQTL GYNIGGNFQS APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ
NSKSVLWGVK ANSFATESGQ KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS
FIATVSHEKG SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY
EVNWKTHEIK VKGQN
