ID   HLGC_STAAN              Reviewed;         315 AA.
AC   Q7A3S2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Gamma-hemolysin component C;
DE   Flags: Precursor;
GN   Name=hlgC; OrderedLocusNames=SA2208;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Toxin that seems to act by forming pores in the membrane of
CC       the cell. Has a hemolytic and a leucotoxic activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Toxicity requires sequential binding and synergistic
CC       association of a class S and a class F component which form
CC       heterooligomeric complexes. HlgC (class S) associates with HlgB (class
CC       F) thus forming an CB toxin (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43510.1; -; Genomic_DNA.
DR   PIR; E90043; E90043.
DR   RefSeq; WP_000916704.1; NC_002745.2.
DR   AlphaFoldDB; Q7A3S2; -.
DR   SMR; Q7A3S2; -.
DR   EnsemblBacteria; BAB43510; BAB43510; BAB43510.
DR   KEGG; sau:SA2208; -.
DR   HOGENOM; CLU_075311_0_0_9; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Hemolysis; Signal; Toxin; Virulence.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..315
FT                   /note="Gamma-hemolysin component C"
FT                   /id="PRO_0000045222"
SQ   SEQUENCE   315 AA;  35584 MW;  DF459166DF16266F CRC64;
     MLKNKILATT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED KTSNKWGVTQ
     NIQFDFVKDK KYNKDALILK MQGFISSRTT YYNYKKTNHV KAMRWPFQYN IGLKTNDKYV
     SLINYLPKNK IESTNVSQTL GYNIGGNFQS APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ
     NSKSVLWGVK ANSFATESGQ KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS
     FIATVSHEKG SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY
     EVNWKTHEIK VKGQN