ID   HLGC_STAAU              Reviewed;         315 AA.
AC   Q07227;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Gamma-hemolysin component C;
DE   AltName: Full=H-gamma-1;
DE   AltName: Full=H-gamma-I;
DE   Flags: Precursor;
GN   Name=hlgC;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8423103; DOI=10.1128/iai.61.2.768-771.1993;
RA   Cooney J.C., Kienle Z., Foster T.J., O'Toole P.W.;
RT   "The gamma-hemolysin locus of Staphylococcus aureus comprises three linked
RT   genes, two of which are identical to the genes for the F and S components
RT   of leukocidin.";
RL   Infect. Immun. 61:768-771(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3075655; DOI=10.1099/00221287-134-8-2179;
RA   Cooney J.C., Mulvey M., Arbuthnott J., Foster T.;
RT   "Molecular cloning and genetic analysis of the determinant for gamma-lysin,
RT   a two-component toxin of Staphylococcus aureus.";
RL   J. Gen. Microbiol. 134:2179-2188(1988).
CC   -!- FUNCTION: Toxin that seems to act by forming pores in the membrane of
CC       the cell. Has a hemolytic and a leucotoxic activity.
CC   -!- SUBUNIT: Toxicity requires sequential binding and synergistic
CC       association of a class S and a class F component which form
CC       heterooligomeric complexes. HlgC (class S) associates with HlgB (class
CC       F) thus forming an CB toxin.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; L01055; AAA26638.1; -; Genomic_DNA.
DR   PIR; C49238; C49238.
DR   RefSeq; WP_000916713.1; NZ_WOUL01000006.1.
DR   AlphaFoldDB; Q07227; -.
DR   SMR; Q07227; -.
DR   TCDB; 1.C.3.4.3; the Alpha-hemolysin channel-forming toxin (Alphahl) family.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Hemolysis; Signal; Toxin; Virulence.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..315
FT                   /note="Gamma-hemolysin component C"
FT                   /id="PRO_0000018426"
SQ   SEQUENCE   315 AA;  35614 MW;  77359819736620BC CRC64;
     MLKNKILTTT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED KTSNKWGVTQ
     NIQFDFVKDK KYNKDALILK MQGFISSRTT YYNYKKTNHV KAMRWPFQYN IGLKTNDKYV
     SLINYLPKNK IESTNVSQTL GYNIGGNFQS APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ
     NSKSVLWGVK ANSFATESGQ KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS
     FIATVSHEKG SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY
     EVNWKTHEIK VKGQN