HLH10_CAEEL
ID HLH10_CAEEL Reviewed; 202 AA.
AC Q23579;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Helix-loop-helix protein 10 {ECO:0000312|WormBase:ZK682.4};
GN Name=hlh-10 {ECO:0000312|WormBase:ZK682.4};
GN Synonyms=CeABF-1 {ECO:0000303|PubMed:11691930};
GN ORFNames=ZK682.4 {ECO:0000312|WormBase:ZK682.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=11691930; DOI=10.1093/nar/29.21.4423;
RA Nguyen L., Round J., O'Connell R., Geurts P., Funes-Duran M., Wong J.,
RA Jongeward G., Vierra C.A.;
RT "Isolation and characterization of the activated B-cell factor 1 homolog in
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 29:4423-4432(2001).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15183729; DOI=10.1016/j.ydbio.2004.02.020;
RA Portman D.S., Emmons S.W.;
RT "Identification of C. elegans sensory ray genes using whole-genome
RT expression profiling.";
RL Dev. Biol. 270:499-512(2004).
RN [4] {ECO:0000305}
RP FUNCTION, HETERODIMER WITH HLH-2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=19632181; DOI=10.1016/j.cell.2009.04.058;
RA Grove C.A., De Masi F., Barrasa M.I., Newburger D.E., Alkema M.J.,
RA Bulyk M.L., Walhout A.J.M.;
RT "A multiparameter network reveals extensive divergence between C. elegans
RT bHLH transcription factors.";
RL Cell 138:314-327(2009).
CC -!- FUNCTION: Probable transcription factor which binds the E box motif 5'-
CC CA[TC][AG]TG-3'. {ECO:0000269|PubMed:19632181}.
CC -!- SUBUNIT: Heterodimer with hlh-2. {ECO:0000269|PubMed:19632181}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:19632181}. Cytoplasm {ECO:0000269|PubMed:19632181}.
CC -!- TISSUE SPECIFICITY: Expressed in intestine, neurons in head, body and
CC tail, and in body hypodermis, and vulva (PubMed:19632181). Expressed in
CC neurons in the male-specific genital sensilla (simple sense organs)
CC known as rays (PubMed:15183729). {ECO:0000269|PubMed:15183729,
CC ECO:0000269|PubMed:19632181}.
CC -!- DEVELOPMENTAL STAGE: Expressed in late embryogenesis, larval stages L2,
CC L3 and L4 and in adults. {ECO:0000269|PubMed:11691930,
CC ECO:0000269|PubMed:19632181}.
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DR EMBL; BX284605; CCD69798.2; -; Genomic_DNA.
DR PIR; T29971; T29971.
DR RefSeq; NP_505401.2; NM_073000.2.
DR AlphaFoldDB; Q23579; -.
DR SMR; Q23579; -.
DR IntAct; Q23579; 1.
DR STRING; 6239.ZK682.4; -.
DR PaxDb; Q23579; -.
DR EnsemblMetazoa; ZK682.4.1; ZK682.4.1; WBGene00001954.
DR GeneID; 191402; -.
DR KEGG; cel:CELE_ZK682.4; -.
DR UCSC; ZK682.4; c. elegans.
DR CTD; 191402; -.
DR WormBase; ZK682.4; CE47615; WBGene00001954; hlh-10.
DR eggNOG; KOG4029; Eukaryota.
DR HOGENOM; CLU_089752_0_0_1; -.
DR InParanoid; Q23579; -.
DR OMA; IDRRMVG; -.
DR OrthoDB; 1582400at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00001954; Expressed in embryo and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..202
FT /note="Helix-loop-helix protein 10"
FT /id="PRO_0000452348"
FT DOMAIN 121..172
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..134
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 135..172
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT COMPBIAS 90..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 23101 MW; 99E37DC64E55F5B0 CRC64;
MESSSMTTHQ EEPLDLSTGN HGNSELSDEQ QIMQVMESCG MFLQQNLFAW FLQSMLEASA
SQPQLTQDEP PENDTKENDL VKQNKSEVND ENESTPSPTQ NSRRRTSTGK IDRRMVGKMC
TRRYEANARE RNRVQQLSKM FDQLRVCLPI EDDAKISKLA TLKVASSYIG YLGAILQENS
NDEEEFKKQL QVELECAKTL RK
