ID   HLH13_CAEEL             Reviewed;         147 AA.
AC   Q20561;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Helix-loop-helix protein 13;
DE   AltName: Full=Fer3-like protein;
DE   AltName: Full=Nephew of atonal 3;
GN   Name=hlh-13 {ECO:0000312|WormBase:F48D6.3};
GN   Synonyms=cnato3 {ECO:0000303|PubMed:11472856},
GN   ferd-3l {ECO:0000312|EMBL:AAK72958.1}; ORFNames=F48D6.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1] {ECO:0000312|EMBL:AAK72958.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11472856; DOI=10.1016/s0925-4773(01)00437-3;
RA   Segev E., Halachmi N., Salzberg A., Ben-Arie N.;
RT   "Nato3 is an evolutionarily conserved bHLH transcription factor expressed
RT   in the CNS of Drosophila and mouse.";
RL   Mech. Dev. 106:197-202(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19103192; DOI=10.1016/j.ydbio.2008.11.019;
RA   Liachko N., Davidowitz R., Lee S.S.;
RT   "Combined informatic and expression screen identifies the novel DAF-16
RT   target HLH-13.";
RL   Dev. Biol. 327:97-105(2009).
CC   -!- FUNCTION: Transcriptional activator (By similarity). Shown to have a
CC       role in the negative regulation of exit from L1 arrest and dauer
CC       diapause dependent on IIS signaling (insulin and insulin-like growth
CC       factor (IGF) signaling). Hypodermal expression is regulated by IIS/daf-
CC       16 while neuronal expression is not under the control of IIS/daf-16.
CC       {ECO:0000250, ECO:0000269|PubMed:19103192}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64305,
CC       ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q64305}.
CC   -!- TISSUE SPECIFICITY: Expressed in hermaphrodite dopaminergic neurons
CC       (ADE, CEP, and PDE). {ECO:0000269|PubMed:19103192}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development and adulthood but
CC       abundance declines with age. {ECO:0000269|PubMed:19103192}.
CC   -!- INDUCTION: Induced by daf-16. {ECO:0000269|PubMed:19103192}.
CC   -!- DISRUPTION PHENOTYPE: Faster exit from L1 arrest and IIS-dependent
CC       dauer diapause. {ECO:0000269|PubMed:19103192}.
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DR   EMBL; AF369899; AAK72958.1; -; Genomic_DNA.
DR   EMBL; FO080925; CCD67847.1; -; Genomic_DNA.
DR   PIR; T29241; T29241.
DR   RefSeq; NP_508725.1; NM_076324.3.
DR   AlphaFoldDB; Q20561; -.
DR   SMR; Q20561; -.
DR   BioGRID; 50731; 1.
DR   IntAct; Q20561; 1.
DR   STRING; 6239.F48D6.3; -.
DR   PaxDb; Q20561; -.
DR   EnsemblMetazoa; F48D6.3.1; F48D6.3.1; WBGene00001957.
DR   GeneID; 185980; -.
DR   KEGG; cel:CELE_F48D6.3; -.
DR   UCSC; F48D6.3; c. elegans.
DR   CTD; 185980; -.
DR   WormBase; F48D6.3; CE07260; WBGene00001957; hlh-13.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00940000165503; -.
DR   HOGENOM; CLU_125146_0_0_1; -.
DR   InParanoid; Q20561; -.
DR   OMA; RRMCSIN; -.
DR   OrthoDB; 1185741at2759; -.
DR   PhylomeDB; Q20561; -.
DR   PRO; PR:Q20561; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00001957; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043054; P:dauer exit; IMP:UniProtKB.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IMP:WormBase.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..147
FT                   /note="Helix-loop-helix protein 13"
FT                   /id="PRO_0000377380"
FT   DOMAIN          41..93
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ   SEQUENCE   147 AA;  16746 MW;  DB8669611D85CA71 CRC64;
     MTASSSGCGG LPVSQCPSYS SLSKLFFMDS SYDSYYCEEP EERQTASIRE RKRMCSINVA
     FIELRNYIPT FPYEKRLSKI DTLNLAIAYI NMLDDVLRTP EDSGQYIQKC VHMARTGQIG
     APAWSTSDLL ARLNWIKWRR LGIEPIA