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HLH25_CAEEL
ID   HLH25_CAEEL             Reviewed;         268 AA.
AC   Q18054;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Helix-loop-helix protein 25 {ECO:0000312|WormBase:C17C3.7};
GN   Name=hlh-25 {ECO:0000312|WormBase:C17C3.7};
GN   ORFNames=C17C3.7 {ECO:0000312|WormBase:C17C3.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=26438299; DOI=10.1534/g3.115.019463;
RA   Chou H.T., Vazquez R.G., Wang K., Campbell R., Milledge G.Z.,
RA   Walthall W.W., Johnson C.M.;
RT   "HES-Mediated Repression of Pten in Caenorhabditis elegans.";
RL   G3 (Bethesda) 5:2619-2628(2015).
CC   -!- FUNCTION: Probable transcription factor (PubMed:26438299). Modulates
CC       lifespan and also recovery from the developmentally arrested larval
CC       state known as dauer, perhaps acting upstream of phosphatase PTEN/daf-
CC       18 (PubMed:26438299). Regulates expression of genes involved in cell
CC       division, cell-cycle regulation, and sexual reproduction, including
CC       daf-18 (PubMed:26438299). {ECO:0000269|PubMed:26438299}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- DEVELOPMENTAL STAGE: Expressed postembryonically at all larval and
CC       adult stages, including the developmentally arrested larval state known
CC       as dauer stage (PubMed:26438299). Expressed in neurons of the head and
CC       tail, including the motor neurons VD1, DA3, and DA7 (PubMed:26438299).
CC       Also expressed in the anal depressor muscle, anterior and posterior
CC       intestinal cells, and the head and body wall muscles (PubMed:26438299).
CC       Expressed in the PDE sensory neuron pairs and rare, transient
CC       expression seen in migrating distal tip cells of larval L3/L4 stages
CC       (PubMed:26438299). {ECO:0000269|PubMed:26438299}.
CC   -!- DISRUPTION PHENOTYPE: Hermaphrodites produce fewer live progeny at 20
CC       degrees Celsius than wild-type, and also laying more unfertilized
CC       oocytes throughout the egg-laying period (PubMed:26438299). Abnormal
CC       gonad morphology (PubMed:26438299). Delayed recovery from the
CC       developmentally arrested larval state known as dauer (PubMed:26438299).
CC       Significantly longer lifespan (PubMed:26438299). Decreased movement
CC       (PubMed:26438299). RNAi-mediated knockdown causes an increase in daf-18
CC       transcripts (PubMed:26438299). {ECO:0000269|PubMed:26438299}.
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DR   EMBL; BX284602; CCD64851.1; -; Genomic_DNA.
DR   RefSeq; NP_495063.2; NM_062662.2.
DR   AlphaFoldDB; Q18054; -.
DR   SMR; Q18054; -.
DR   IntAct; Q18054; 11.
DR   STRING; 6239.C17C3.7; -.
DR   PaxDb; Q18054; -.
DR   EnsemblMetazoa; C17C3.7.1; C17C3.7.1; WBGene00001964.
DR   GeneID; 182717; -.
DR   KEGG; cel:CELE_C17C3.7; -.
DR   UCSC; C17C3.7; c. elegans.
DR   CTD; 182717; -.
DR   WormBase; C17C3.7; CE42919; WBGene00001964; hlh-25.
DR   eggNOG; ENOG502TKHE; Eukaryota.
DR   GeneTree; ENSGT00970000196840; -.
DR   HOGENOM; CLU_1162055_0_0_1; -.
DR   InParanoid; Q18054; -.
DR   OrthoDB; 1891977at2759; -.
DR   PhylomeDB; Q18054; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001964; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..268
FT                   /note="Helix-loop-helix protein 25"
FT                   /id="PRO_0000455601"
FT   DOMAIN          92..149
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          92..105
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          106..149
FT                   /note="Helix-loop-helix motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  31156 MW;  D65BB527AC3D38BE CRC64;
     MPKVIQSSMS DYRSVPYNQT PKSASERKRR NITNELINEC KTIVQKSEEE HISQEVVLFR
     IVKLVTGVNL ESNFSSNDLS ESTRRKFDTE SERRKVKTER EKIRRKKQDD CYAELKFFIL
     NKQMGSYEQR LKLERITILE IIIDYIKHNS DLLYPETIPQ ILPLLAGKST ATCENKENEK
     PKTRMEVKDL FPRLTFQEVQ ESPTSTSPLL TFPCIPMIPT TQFNVLSNYN TVPSIFSAPL
     RFILPSLQIL TPETSDEEEN EETLDIIN
 
 
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