ID   HLH34_CAEEL             Reviewed;         322 AA.
AC   P90953; Q963J3;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 3.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Helix-loop-helix 34;
GN   Name=hlh-34; ORFNames=T01D3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB03258.2};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=11427734; DOI=10.1073/pnas.141234698;
RA   Jiang H., Guo R., Powell-Coffman J.A.;
RT   "The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is
RT   required for adaptation to hypoxia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7916-7921(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Transcription factor that may be a master gene of CNS
CC       development in cooperation with Arnt. It may have pleiotropic effects
CC       in the tissues expressed during development (By similarity).
CC       {ECO:0000250|UniProtKB:Q14190}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000250|UniProtKB:Q14190}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AF370362; AAK52515.1; -; mRNA.
DR   EMBL; Z81110; CAB03258.2; -; Genomic_DNA.
DR   PIR; T24292; T24292.
DR   RefSeq; NP_506391.2; NM_073990.3.
DR   AlphaFoldDB; P90953; -.
DR   SMR; P90953; -.
DR   BioGRID; 44875; 2.
DR   IntAct; P90953; 2.
DR   STRING; 6239.T01D3.2; -.
DR   PaxDb; P90953; -.
DR   EnsemblMetazoa; T01D3.2.1; T01D3.2.1; WBGene00011327.
DR   GeneID; 179860; -.
DR   KEGG; cel:CELE_T01D3.2; -.
DR   UCSC; T01D3.2; c. elegans.
DR   CTD; 179860; -.
DR   WormBase; T01D3.2; CE30446; WBGene00011327; hlh-34.
DR   eggNOG; KOG3559; Eukaryota.
DR   HOGENOM; CLU_863913_0_0_1; -.
DR   InParanoid; P90953; -.
DR   OMA; QRRQMEN; -.
DR   OrthoDB; 922461at2759; -.
DR   PhylomeDB; P90953; -.
DR   PRO; PR:P90953; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00011327; Expressed in pharyngeal muscle cell (C elegans) and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00130; PAS; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Helix-loop-helix 34"
FT                   /id="PRO_0000127443"
FT   DOMAIN          8..62
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   DOMAIN          82..152
FT                   /note="PAS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140,
FT                   ECO:0000305"
FT   DOMAIN          203..276
FT                   /note="PAS 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q14190,
FT                   ECO:0000255|PROSITE-ProRule:PRU00140"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  36762 MW;  487A9403447337CD CRC64;
     METNLSEEKQ KPSKSQAQQR RQMENYEFSQ LANELPLARA ISGQHIDKTT MVRLATAYIK
     LHNIFGQSQR AYSSADYYYG SDSLWTNNHL DLLDGFFVIL DRRGDVLYIS ETISIYLGLS
     QVEMTGNAMV DYIHEQDINC FNSALNYCDL NWPQMCNVRV KSSLTKRANK DAVRASPGYK
     VLRLEITMGP NTNTRMIACY PMPTPVLSTV TIPSNSFVII TSIDLHITFA DEKAHQLLNN
     PFYPDSNIKG MSLYSLIDIS DSEVISKMHF DIFNLGAYKT PYYRMILNQT SETFYVESNI
     FRHTSISSKQ FNDSITFVSS IL