ID   HLOA_HALAU              Reviewed;          18 AA.
AC   P83705;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Halocidin subunit A;
OS   Halocynthia aurantium (Sea peach).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=254849 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, SUBUNIT, AMIDATION AT ALA-18, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:12067731};
RX   PubMed=12067731; DOI=10.1016/s0014-5793(02)02827-2;
RA   Jang W.S., Kim K.N., Lee Y.S., Nam M.H., Lee I.H.;
RT   "Halocidin: a new antimicrobial peptide from hemocytes of the solitary
RT   tunicate, Halocynthia aurantium.";
RL   FEBS Lett. 521:81-86(2002).
CC   -!- FUNCTION: Antimicrobial activity against S.aureus and P.aeruginosa,
CC       possibly by attacking the bacterial cell membrane.
CC       {ECO:0000269|PubMed:12067731, ECO:0000303|PubMed:12067731}.
CC   -!- SUBUNIT: Heterodimer with subunit B; disulfide-linked.
CC       {ECO:0000269|PubMed:12067731}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=1929.91; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12067731};
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DR   AlphaFoldDB; P83705; -.
DR   GO; GO:0005576; C:extracellular region; IC:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
DR   InterPro; IPR012516; Antimicrobial13.
DR   Pfam; PF08108; Antimicrobial13; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Halocidin subunit A"
FT                   /id="PRO_0000044144"
FT   MOD_RES         18
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:12067731"
FT   DISULFID        12
FT                   /note="Interchain (with C-9 in subunit B)"
SQ   SEQUENCE   18 AA;  1930 MW;  E658D9AB451FF2ED CRC64;
     WLNALLHHGL NCAKGVLA