ID   HLOX2_HELRO             Reviewed;         429 AA.
AC   Q01622;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Homeobox protein LOX2;
DE   Flags: Fragment;
GN   Name=LOX2;
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1363227; DOI=10.1242/dev.116.3.697;
RA   Nardelli-Haefliger D., Shankland M.;
RT   "Lox2, a putative leech segment identity gene, is expressed in the same
RT   segmental domain in different stem cell lineages.";
RL   Development 116:697-710(1992).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. May play a role
CC       in midgut regionalization.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Restricted to the posterior 16 midbody segments.
CC       Expressed in the dorsoventral muscles, which arise from the septal
CC       mesoderm and lie in the groove of the intercaecal constrictions.
CC   -!- DEVELOPMENTAL STAGE: Largest accumulation of transcripts is seen in the
CC       posterior 16 midbody segments of the leech embryo between days 7 and
CC       14.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; Z14313; CAA78665.1; -; mRNA.
DR   PIR; A49130; S24705.
DR   AlphaFoldDB; Q01622; -.
DR   SMR; Q01622; -.
DR   STRING; 6412.HelroP78362; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..429
FT                   /note="Homeobox protein LOX2"
FT                   /id="PRO_0000200256"
FT   DNA_BIND        217..276
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   429 AA;  47016 MW;  980F1C0DCA445368 CRC64;
     NNNNNINNNN SRLNIATSSS ATPSTTFQQK SPYYDTTTST TVTSLTSTDY SSYQQQQQLL
     LAEFDTDYKE NAEQFADVSV QNVNISCSNS NNNNTDLNNN SSKCMNNSNI IIDNNSTDSF
     QQKQHPETTE DTKYNAETEE DRKSHGKAFG GHFASSRYGI DDDVISNRTG SRPSSPASTT
     PSCENFSPHS PSMKGGKMGS APSYPWMSIV GPNSNQRRRG RQTYTRYQTL ELEKEFKFNR
     YLTRRRRIEL SHTLYLTERQ IKIWFQNRRM KEKKEVQAIR ELNEIEKTKI GCFGSLRSPC
     DDDDDDDDDI DGSGSSGVCG VASGGIGGGD CRKVSGNSGS SRNGLSSNGG NVMGGINGAG
     GGANVVNHDE LITSCRDVPS QQNCLNGNNN NNNNINNNNI NNNNGVEMMV GMVCSSGRMM
     MEGVDYGGG