ID   HLOX2_HIRME             Reviewed;         118 AA.
AC   P21523;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox protein LOX2;
DE   Flags: Fragment;
GN   Name=LOX2;
OS   Hirudo medicinalis (Medicinal leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Hirudo.
OX   NCBI_TaxID=6421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2571941; DOI=10.1038/341760a0;
RA   Wysocka-Diller J.W., Aisemberg G.O., Baumgarten M., Levine M.,
RA   Macagno E.R.;
RT   "Characterization of a homologue of bithorax-complex genes in the leech
RT   Hirudo medicinalis.";
RL   Nature 341:760-763(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Largest accumulation of transcripts is seen in the
CC       posterior two-thirds of the developing leech central nervous system in
CC       7-14 days embryos.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X17566; CAA35595.1; -; Genomic_DNA.
DR   PIR; S06493; S06493.
DR   AlphaFoldDB; P21523; -.
DR   SMR; P21523; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..118
FT                   /note="Homeobox protein LOX2"
FT                   /id="PRO_0000200257"
FT   DNA_BIND        6..65
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          81..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   118 AA;  13793 MW;  960464914E2AF6D4 CRC64;
     PNSNQRRRGR QTYTRYQTLE LEKEFKFNRY LTRRRRIELS HTLYLTERQI KIWFQNRRMK
     EKKEVQAIRE LNEIEKTKLG GFLGSARSPS STTSASCHGT GSSLSPPLME MGGHSSAE