HLPDA_MOUSE
ID HLPDA_MOUSE Reviewed; 64 AA.
AC Q9JLS0; Q3UMU3; Q8VDY1;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Hypoxia-inducible lipid droplet-associated protein;
DE AltName: Full=Hypoxia-inducible gene 2 protein;
GN Name=Hilpda; Synonyms=Hig2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schindler C., Denko N.C., Koong A.C., Giaccia A.J.;
RT "Murine HIG2 - a novel hypoxia-induced gene.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION.
RX PubMed=20624928; DOI=10.1096/fj.10-159806;
RA Gimm T., Wiese M., Teschemacher B., Deggerich A., Schodel J., Knaup K.X.,
RA Hackenbeck T., Hellerbrand C., Amann K., Wiesener M.S., Honing S.,
RA Eckardt K.U., Warnecke C.;
RT "Hypoxia-inducible protein 2 is a novel lipid droplet protein and a
RT specific target gene of hypoxia-inducible factor-1.";
RL FASEB J. 24:4443-4458(2010).
CC -!- FUNCTION: Increases intracellular lipid accumulation. Stimulates
CC expression of cytokines including IL6, MIF and VEGFA. Enhances cell
CC growth and proliferation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250}. Secreted
CC {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein
CC {ECO:0000305}.
CC -!- INDUCTION: By hypoxia (at protein level).
CC {ECO:0000269|PubMed:20624928}.
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DR EMBL; AF141311; AAF25720.1; -; mRNA.
DR EMBL; AK009377; BAB26253.1; -; mRNA.
DR EMBL; AK144676; BAE26005.1; -; mRNA.
DR EMBL; BC020081; AAH20081.1; -; mRNA.
DR EMBL; BC083056; AAH83056.1; -; mRNA.
DR CCDS; CCDS39450.1; -.
DR RefSeq; NP_076005.1; NM_023516.5.
DR AlphaFoldDB; Q9JLS0; -.
DR SMR; Q9JLS0; -.
DR STRING; 10090.ENSMUSP00000060791; -.
DR iPTMnet; Q9JLS0; -.
DR PhosphoSitePlus; Q9JLS0; -.
DR PaxDb; Q9JLS0; -.
DR PRIDE; Q9JLS0; -.
DR ProteomicsDB; 273148; -.
DR Antibodypedia; 2129; 29 antibodies from 12 providers.
DR DNASU; 69573; -.
DR Ensembl; ENSMUST00000054445; ENSMUSP00000060791; ENSMUSG00000043421.
DR Ensembl; ENSMUST00000115289; ENSMUSP00000110944; ENSMUSG00000043421.
DR GeneID; 69573; -.
DR KEGG; mmu:69573; -.
DR UCSC; uc009bdd.2; mouse.
DR CTD; 29923; -.
DR MGI; MGI:1916823; Hilpda.
DR VEuPathDB; HostDB:ENSMUSG00000043421; -.
DR eggNOG; ENOG502T735; Eukaryota.
DR GeneTree; ENSGT00390000014201; -.
DR HOGENOM; CLU_192601_0_0_1; -.
DR InParanoid; Q9JLS0; -.
DR OMA; TIHPEGC; -.
DR OrthoDB; 1628130at2759; -.
DR Reactome; R-MMU-8964572; Lipid particle organization.
DR BioGRID-ORCS; 69573; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Hilpda; mouse.
DR PRO; PR:Q9JLS0; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9JLS0; protein.
DR Bgee; ENSMUSG00000043421; Expressed in right lung lobe and 186 other tissues.
DR Genevisible; Q9JLS0; MM.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005811; C:lipid droplet; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
DR GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
DR GO; GO:0035425; P:autocrine signaling; ISS:UniProtKB.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0010884; P:positive regulation of lipid storage; ISS:UniProtKB.
DR InterPro; IPR026190; Hipoxia_HILPDA.
DR PANTHER; PTHR16886; PTHR16886; 1.
DR Pfam; PF15220; HILPDA; 1.
PE 1: Evidence at protein level;
KW Lipid droplet; Membrane; Reference proteome; Secreted; Stress response;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..64
FT /note="Hypoxia-inducible lipid droplet-associated protein"
FT /id="PRO_0000083977"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Required for targeting to lipid droplets"
FT /evidence="ECO:0000250"
FT REGION 42..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="G -> R (in Ref. 3; AAH20081)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 64 AA; 7007 MW; 3F909AD81DC979AD CRC64;
MKFMLNLYVL GIMLTLLSIF VRVMESLGGL LESPLPGSSW ITRGQLANTQ PPKGLPDHPS
RGVQ
