HLR1_YEAST
ID HLR1_YEAST Reviewed; 423 AA.
AC Q04429; D6VTE9;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein HLR1;
DE AltName: Full=LRE1 homolog;
GN Name=HLR1; OrderedLocusNames=YDR528W; ORFNames=D9719.31;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=11580836; DOI=10.1046/j.1365-2958.2001.02590.x;
RA Versele M., Thevelein J.M.;
RT "Lre1 affects chitinase expression, trehalose accumulation and heat
RT resistance through inhibition of the Cbk1 protein kinase in Saccharomyces
RT cerevisiae.";
RL Mol. Microbiol. 41:1311-1326(2001).
RN [4]
RP FUNCTION.
RX PubMed=11532139; DOI=10.1046/j.1365-2958.2001.02549.x;
RA Alonso-Monge R., Real E., Wojda I., Bebelman J.-P., Mager W.H.,
RA Siderius M.;
RT "Hyperosmotic stress response and regulation of cell wall integrity in
RT Saccharomyces cerevisiae share common functional aspects.";
RL Mol. Microbiol. 41:717-730(2001).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in cell wall composition and integrity and response
CC to osmotic stress. {ECO:0000269|PubMed:11532139,
CC ECO:0000269|PubMed:11580836}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 259 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U33057; AAB64967.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12359.1; -; Genomic_DNA.
DR PIR; S69583; S69583.
DR RefSeq; NP_010817.3; NM_001180836.3.
DR AlphaFoldDB; Q04429; -.
DR BioGRID; 32577; 48.
DR DIP; DIP-4293N; -.
DR IntAct; Q04429; 3.
DR MINT; Q04429; -.
DR STRING; 4932.YDR528W; -.
DR iPTMnet; Q04429; -.
DR MaxQB; Q04429; -.
DR PaxDb; Q04429; -.
DR PRIDE; Q04429; -.
DR EnsemblFungi; YDR528W_mRNA; YDR528W; YDR528W.
DR GeneID; 852141; -.
DR KEGG; sce:YDR528W; -.
DR SGD; S000002936; HLR1.
DR VEuPathDB; FungiDB:YDR528W; -.
DR eggNOG; ENOG502RXFV; Eukaryota.
DR GeneTree; ENSGT00940000176546; -.
DR HOGENOM; CLU_671133_0_0_1; -.
DR InParanoid; Q04429; -.
DR OMA; NNAGRIN; -.
DR BioCyc; YEAST:G3O-30042-MON; -.
DR PRO; PR:Q04429; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q04429; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IGI:SGD.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Cytoplasm; Reference proteome.
FT CHAIN 1..423
FT /note="Protein HLR1"
FT /id="PRO_0000083991"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 47578 MW; 27939765B073F068 CRC64;
MENLCPPPPS QMKDFSTPPR NRHRHKRSFA ISGDFEFLKQ PASAPVLPSA YDSPTFENTP
RRVSGMSVTM PDESQNESAL LNSPSPRFFI SEASTYSSPI KGVPDAIINL DDVLINKPKM
CRSHRKTKSV PVKLDEFYSS HKCSSVPELT INEEIDEDDT NPQLLEPVKP LSSTSLSTDM
NEDKKMTLKN ARSHNSLKIQ AQKQRYYNSA RYLPLNSEDR ATDPQILTKQ SSVTSLFSSR
SITPVSCNIN NAGRINAISG NYLDDVLYDL DTPATTLIQD IDNLQTSINE RVRLSPQSSS
IKKYFSKDGK SVSSFNFQSQ ECDMVSFTED FAHVTSLSSS ILDSEKQTDD EEEESIPEEI
LRGEPLHVYN ETSGSDKSVI LPTKQKSAPI NKDSKHSSTQ YEEKSFKKNR KFKIFAKLFC
TRK
