ID   HLX_BOVIN               Reviewed;         486 AA.
AC   A7MB54;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=H2.0-like homeobox protein;
DE   AltName: Full=Homeobox protein HLX1;
GN   Name=HLX; Synonyms=HLX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI51346.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI51346.1};
RC   TISSUE=Uterus {ECO:0000312|EMBL:AAI51346.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for TBX21/T-bet-dependent
CC       maturation of Th1 cells as well as maintenance of Th1-specific gene
CC       expression. Involved in embryogenesis and hematopoiesis (By
CC       similarity). {ECO:0000250|UniProtKB:Q61670}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P52950,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000255}.
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DR   EMBL; BC151345; AAI51346.1; -; mRNA.
DR   RefSeq; NP_001094567.1; NM_001101097.1.
DR   AlphaFoldDB; A7MB54; -.
DR   SMR; A7MB54; -.
DR   STRING; 9913.ENSBTAP00000019352; -.
DR   PaxDb; A7MB54; -.
DR   PRIDE; A7MB54; -.
DR   Ensembl; ENSBTAT00000019352; ENSBTAP00000019352; ENSBTAG00000014560.
DR   GeneID; 519165; -.
DR   KEGG; bta:519165; -.
DR   CTD; 3142; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014560; -.
DR   VGNC; VGNC:50277; HLX.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_043671_1_0_1; -.
DR   InParanoid; A7MB54; -.
DR   OMA; EPMNEAS; -.
DR   OrthoDB; 1596695at2759; -.
DR   TreeFam; TF350735; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000014560; Expressed in laryngeal cartilage and 97 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0048484; P:enteric nervous system development; IEA:Ensembl.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR   GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR   GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR   GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..486
FT                   /note="H2.0-like homeobox protein"
FT                   /id="PRO_0000311699"
FT   DNA_BIND        276..335
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          83..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..376
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..486
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  50415 MW;  FEE84B9889998965 CRC64;
     MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL HAGVGEPGAT
     PEGLAGASAA ALTAHLGSAH PHASFQAAAR SPLRPTPVVA PSEVPAGFPQ RLSPLSAAYH
     HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP ASGSRVVPNP HQSGSAPAPS SKDLKFGIDR
     ILSAEFDPKV KEGNTLRDLT SLLTGGRPAG VHLPGLQPSA GQFFASLDPI NEASAILSPL
     SSNPRNSVQH QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY
     VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK PSGGAPAPDG
     EPEERSPSRS EGEAESESSD PESLDMAPSD TERTEGTERS LHQTTVIKAS AAGALLAASS
     GGSGGSGGGG GGGFNFGGLS SGSTTSAGSS GSHSSGGASE LLPAPQPSLS SAPKSPEPVP
     APLGGL