ID   HLX_RAT                 Reviewed;         476 AA.
AC   A0JPN1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=H2.0-like homeobox protein;
DE   AltName: Full=Homeobox protein HLX1;
GN   Name=Hlx; Synonyms=Hlx1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAI27514.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung {ECO:0000312|EMBL:AAI27514.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription factor required for TBX21/T-bet-dependent
CC       maturation of Th1 cells as well as maintenance of Th1-specific gene
CC       expression. Involved in embryogenesis and hematopoiesis (By
CC       similarity). {ECO:0000250|UniProtKB:Q61670}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P52950,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC127513; AAI27514.1; -; mRNA.
DR   RefSeq; NP_001071142.1; NM_001077674.1.
DR   AlphaFoldDB; A0JPN1; -.
DR   SMR; A0JPN1; -.
DR   STRING; 10116.ENSRNOP00000003155; -.
DR   PhosphoSitePlus; A0JPN1; -.
DR   PaxDb; A0JPN1; -.
DR   PRIDE; A0JPN1; -.
DR   Ensembl; ENSRNOT00000003155; ENSRNOP00000003155; ENSRNOG00000002309.
DR   GeneID; 364069; -.
DR   KEGG; rno:364069; -.
DR   UCSC; RGD:1311961; rat.
DR   CTD; 3142; -.
DR   RGD; 1311961; Hlx.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_043671_1_0_1; -.
DR   InParanoid; A0JPN1; -.
DR   OMA; EPMNEAS; -.
DR   OrthoDB; 1596695at2759; -.
DR   PhylomeDB; A0JPN1; -.
DR   TreeFam; TF350735; -.
DR   PRO; PR:A0JPN1; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000002309; Expressed in esophagus and 19 other tissues.
DR   Genevisible; A0JPN1; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0048513; P:animal organ development; ISO:RGD.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISO:RGD.
DR   GO; GO:0048484; P:enteric nervous system development; ISO:RGD.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; ISO:RGD.
DR   GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; ISO:RGD.
DR   GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0046622; P:positive regulation of organ growth; ISO:RGD.
DR   GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; ISO:RGD.
DR   GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR   GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..476
FT                   /note="H2.0-like homeobox protein"
FT                   /id="PRO_0000311700"
FT   DNA_BIND        273..332
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          121..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..146
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  50027 MW;  961BF78D0C817944 CRC64;
     MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFALDPAAVK KPSFCIADIL HAGVGEPGPA
     AEGLVGASAA LTAHLGSVHP HASFQAAARS PLRPTPVVAP SEVPAGFPQR LSPLSAAYHQ
     HLPQQPPTQQ QQPQQQPPPP PRAGSLQPPT SGTRVVPHHS GSAPAPSSKD LKFGIDRILS
     AEFDPKVKEG NTLRDLTSLL TGGRPTGVHL AGLQPSAGQF FASLDPISEA SAILSPLSSN
     PRNSVQHQFQ DTFPGPYAVL TKDTMPQTYK RKRSWSRAVF SNLQRKGLEK RFEIQKYVTK
     PDRKQLAAML GLTDAQVKVW FQNRRMKWRH SKEAQAQKDK DKEAGEKPSG GVPAEGEREE
     RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKASAAGA LITASSSASG
     SSFSFSSSSS LGSSNGSAGS ASSLGSNCSE LLPSHQPSVT SGPQSPEIAQ VPLAGL