HLY1_AERHH
ID HLY1_AERHH Reviewed; 621 AA.
AC P55870; A0KIE9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Hemolysin ahh1;
DE Flags: Precursor;
GN Name=ahh1; OrderedLocusNames=AHA_1512;
OS Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=380703;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC 2358 / NCIMB 9240 / NCTC 8049;
RX PubMed=16980456; DOI=10.1128/jb.00621-06;
RA Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL J. Bacteriol. 188:8272-8282(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-621.
RX PubMed=1800890; DOI=10.1016/0882-4010(91)90049-g;
RA Hirono I., Aoki T.;
RT "Nucleotide sequence and expression of an extracellular hemolysin gene of
RT Aeromonas hydrophila.";
RL Microb. Pathog. 11:189-197(1991).
CC -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC membranes and cause cell rupture by mechanisms not clearly defined.
CC -!- SIMILARITY: Belongs to the HlyA hemolysin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=Ref.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CP000462; ABK36614.1; -; Genomic_DNA.
DR PIR; A61372; A61372.
DR RefSeq; WP_011705409.1; NC_008570.1.
DR RefSeq; YP_856050.1; NC_008570.1.
DR AlphaFoldDB; P55870; -.
DR SMR; P55870; -.
DR STRING; 380703.AHA_1512; -.
DR TCDB; 1.C.14.1.2; the cytohemolysin (chl) family.
DR PRIDE; P55870; -.
DR EnsemblBacteria; ABK36614; ABK36614; AHA_1512.
DR KEGG; aha:AHA_1512; -.
DR PATRIC; fig|380703.7.peg.1525; -.
DR eggNOG; ENOG502ZBG7; Bacteria.
DR HOGENOM; CLU_439829_0_0_6; -.
DR OMA; HVAFYLN; -.
DR Proteomes; UP000000756; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 3.30.110.130; -; 1.
DR Gene3D; 6.20.40.20; -; 1.
DR InterPro; IPR022220; Hemolysin_N.
DR InterPro; IPR043080; Hemolysin_N_sf.
DR InterPro; IPR044883; Hemolysin_pre-stem_dom_sf.
DR InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF12563; Hemolysin_N; 1.
DR Pfam; PF07968; Leukocidin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF50370; SSF50370; 1.
DR SUPFAM; SSF56959; SSF56959; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Cytolysis; Hemolysis; Lectin; Reference proteome; Signal; Toxin; Virulence.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..621
FT /note="Hemolysin ahh1"
FT /id="PRO_0000013366"
FT DOMAIN 491..610
FT /note="Ricin B-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT CONFLICT 64
FT /note="R -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="S -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="T -> A (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="V -> L (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 157..158
FT /note="KR -> NG (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="G -> A (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="T -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 289..290
FT /note="SI -> TT (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="T -> A (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="C -> F (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 527
FT /note="F -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="Q -> E (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 542
FT /note="R -> L (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="G -> V (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 621 AA; 68907 MW; 99C8E4BD6055381D CRC64;
MKNKKPRKFI TQAPTLSLLA LALLAGSVQA EDIGERTDQG TAMLASLQSE QGLIYLNADV
WLKRQGATPL MTRDQLRERV LARGERLFID FSAVTDQSER QQTRKAMEQL AGISFDADWV
LVSGYKGELL FTPLGGVDDP AFYQVMERVE SLEGQGKRHK RSLTQPPAAE AGLPHVAFYL
NVNRKISDAE CTFPRSRTWS RGDRLFCDSP NISLVYRVNL ERSLQFGNTG SATPDAKIVR
ISLDEESAGA GIQLNEDLTW SENIADYLLL DGWARDYATD AIAQDYRFSI EASNTKAAVL
KSLPTNLNSK YEHREISGFE VGVTGGVEVN KDGPKAKLEA SAKFSQQRQL AYNTQDYRVE
RSAPSAQKVS FSWVRDQYAT AESLLSSKTA TVWGMGYDVD HNRIQPLSYK GFVPNLDVIY
KAAPDETGST EFKIDSSVNI RPIYTGIYKH YYVVGAHVSF QGFEDTDKRR RVTASTSFKV
DWNHPVFTGG RPVNLQLGGF DNRCLSADAN HGLSAVTCDE TSAAQSFIYD QYGRYVSAQD
TRRCLDGNNL GQLQSCSLSL GQRWEWKADS DALSNLSAHQ LLGHDKQSGA LGLYDENGNP
QNVSVRTLTS YTRIFGPPAS H
