ID   HLY1_AERSA              Reviewed;         572 AA.
AC   Q08675;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Hemolysin-1;
GN   Name=ash1;
OS   Aeromonas salmonicida.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=645;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14174 / NBRC 12659 / NCIMB 833;
RX   PubMed=8309354; DOI=10.1006/mpat.1993.1077;
RA   Hirono I., Aoki T.;
RT   "Cloning and characterization of three hemolysin genes from Aeromonas
RT   salmonicida.";
RL   Microb. Pathog. 15:269-282(1993).
CC   -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC       membranes and cause cell rupture by mechanisms not clearly defined.
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DR   EMBL; X65047; CAA46183.1; -; Genomic_DNA.
DR   PIR; I39674; I39674.
DR   AlphaFoldDB; Q08675; -.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR008947; PLipase_C/P1_nuclease_dom_sf.
DR   SUPFAM; SSF48537; SSF48537; 1.
PE   4: Predicted;
KW   Cytolysis; Hemolysis; Toxin; Virulence.
FT   CHAIN           1..572
FT                   /note="Hemolysin-1"
FT                   /id="PRO_0000196251"
SQ   SEQUENCE   572 AA;  64781 MW;  3C318291A4C34B07 CRC64;
     MNIKKLSLCI FFATTQVHAF TQWGAGGITP MGHEWLTRTS ALEVLNAEHK TSVDPNDPRN
     TWTSGLAKNI DISTADDEVA KIKSHTNDNS LYAPRSDAVY SAIVGQRWVD LGGMNVANNL
     ISQTGPDCFD AVSQEPADIQ QDHFMRRYDD NGQQGGVKSA QRGQERFITH FINAAMATNK
     RIVVWDGGGS SAKTDVDYNY FLFGRAVHLF QDSFSPEHVV RSPSDNYEKV RQVKAYICTE
     GAEQHAHSTG AVLDYTSGDV IWKVGTKTDT GWGGYKASNM KPVALVAMEA SKDLWAAFMR
     TMSVDINERE KYARNEAQVL IDKWMSFDKD EMEHWYDNEN NRDNTYVKVD GDTGKGKLQK
     ECMSGLSAKN RYGATIKPKT QKELVDVLDD SRRYCLFNIE AEPGYADAND PYLNIPFNWR
     WKSNSWLVPN ASWQQKQLDR DTGKIIKIKE FTNNQELTVD SIENNYSIVT GAKKPLSLVR
     VPGDGGKSFY LRSKDNPYLF FSYSDKKNGR IKLWHSPNQA EFEILPGNNI FNLKNTYWNQ
     YVWYDKNSKG AYLTEKGSPD NASSKWIISE EN