HLY1_GRIHO
ID HLY1_GRIHO Reviewed; 189 AA.
AC P28031;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Thermostable direct hemolysin;
DE Flags: Precursor;
GN Name=tdh;
OS Grimontia hollisae (Vibrio hollisae).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Grimontia.
OX NCBI_TaxID=673;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=9041;
RX PubMed=1884983; DOI=10.1016/0378-1097(91)90606-b;
RA Yamasaki S., Shirai H., Takeda Y., Nishibuchi M.;
RT "Analysis of the gene of Vibrio hollisae encoding the hemolysin similar to
RT the thermostable direct hemolysin of Vibrio parahaemolyticus.";
RL FEMS Microbiol. Lett. 64:259-263(1991).
CC -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC membranes and cause cell rupture by mechanisms not clearly defined.
CC -!- SUBUNIT: Homodimer.
CC -!- SIMILARITY: Belongs to the TDH hemolysin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M57900; AAA27570.1; -; Genomic_DNA.
DR PIR; A54544; A54544.
DR AlphaFoldDB; P28031; -.
DR SMR; P28031; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.270.30; -; 1.
DR InterPro; IPR038689; TDH_sf.
DR InterPro; IPR005015; Thermostable_hemolysn_vibrio.
DR Pfam; PF03347; TDH; 1.
PE 3: Inferred from homology;
KW Cytolysis; Disulfide bond; Hemolysis; Signal; Toxin; Virulence.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..189
FT /note="Thermostable direct hemolysin"
FT /id="PRO_0000013360"
FT DISULFID 175..185
FT /evidence="ECO:0000250"
SQ SEQUENCE 189 AA; 21521 MW; CB486133F308D0BF CRC64;
MKYRHLAKKS FLFIFMLAAF KTFAFELPSI PFPSPGSDEI LFVVRDTTFN TKEPVNVKVS
DFWTNRNVKR KPYKDVHGQS VFITSGTKWL TSYMTVSINN KDYTMAAVSG YKDGFSSVFV
KSGQIQLQHY YNSVADFVGG DENSIPSKTY LDETPEYFVN VEAYESGSGN ILVMCISNKE
SYFECESQQ