ID   HLY2C_STACC             Reviewed;          18 AA.
AC   P85220;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Hemolysin H2C;
OS   Staphylococcus cohnii subsp. cohnii.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=74704;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   FORMYLATION AT MET-1.
RC   STRAIN=ZMF 77 {ECO:0000269|PubMed:18752624};
RX   PubMed=18752624; DOI=10.1111/j.1574-6968.2008.01321.x;
RA   Mak P., Maszewska A., Rozalska M.;
RT   "The amino acid sequences and activities of synergistic hemolysins from
RT   Staphylococcus cohnii.";
RL   FEMS Microbiol. Lett. 287:230-235(2008).
CC   -!- FUNCTION: Virulence factor. Causes hemolysis of erythrocytes from sheep
CC       (HD(50)=4.79 mM), rabbit (HD(50)=8.76 mM), guinea pig (HD(50)=2.00 mM),
CC       dog (HD(50)=5.35 mM) and human (HD(50)=6.34 mM). Acts synergistically
CC       with beta-hemolysins from S.aureus ATCC 25923. Cytotoxic towards human
CC       dermal fibroblasts. {ECO:0000269|PubMed:18752624}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18752624}.
CC   -!- MASS SPECTROMETRY: Mass=2078.4; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:18752624};
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DR   AlphaFoldDB; P85220; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Formylation; Hemolysis; Secreted;
KW   Toxin; Virulence.
FT   PEPTIDE         1..18
FT                   /note="Hemolysin H2C"
FT                   /id="PRO_0000302138"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000269|PubMed:18752624"
SQ   SEQUENCE   18 AA;  2052 MW;  C028EDEEBE2615BB CRC64;
     MDFIIDIIKK IVGLFTGK