HLY2U_STAUR
ID HLY2U_STAUR Reviewed; 18 AA.
AC P85223;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Hemolysin H2U;
OS Staphylococcus ureilyticus (Staphylococcus cohnii subsp. urealyticus).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=94138;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP FORMYLATION AT MET-1.
RC STRAIN=ZMF 535 {ECO:0000269|PubMed:18752624};
RX PubMed=18752624; DOI=10.1111/j.1574-6968.2008.01321.x;
RA Mak P., Maszewska A., Rozalska M.;
RT "The amino acid sequences and activities of synergistic hemolysins from
RT Staphylococcus cohnii.";
RL FEMS Microbiol. Lett. 287:230-235(2008).
CC -!- FUNCTION: Virulence factor. Causes hemolysis of erythrocytes. Acts
CC synergistically with beta-hemolysins from S.aureus ATCC 25923.
CC Cytotoxic towards human dermal fibroblasts.
CC {ECO:0000269|PubMed:18752624}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18752624}.
CC -!- MASS SPECTROMETRY: Mass=2079.7; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:18752624};
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DR AlphaFoldDB; P85223; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytolysis; Direct protein sequencing; Formylation; Hemolysis; Secreted;
KW Toxin; Virulence.
FT PEPTIDE 1..18
FT /note="Hemolysin H2U"
FT /id="PRO_0000302139"
FT MOD_RES 1
FT /note="N-formylmethionine"
FT /evidence="ECO:0000269|PubMed:18752624"
SQ SEQUENCE 18 AA; 2052 MW; C028EDEEBE2615BB CRC64;
MDFIIDIIKK IVGLFTGK