ID   ANXA6_RABIT             Reviewed;          40 AA.
AC   Q9TS53;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   RecName: Full=Annexin A6;
DE   AltName: Full=Annexin VI;
DE   AltName: Full=Annexin-6;
DE   Flags: Fragments;
GN   Name=ANXA6 {ECO:0000250|UniProtKB:P08133};
GN   Synonyms=ANX6 {ECO:0000250|UniProtKB:P08133};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Liver {ECO:0000269|PubMed:8967522};
RX   PubMed=8967522; DOI=10.1152/ajplung.1996.270.5.l863;
RA   Mayran N., Traverso V., Maroux S., Massey-Harroche D.;
RT   "Cellular and subcellular localizations of annexins I, IV, and VI in lung
RT   epithelia.";
RL   Am. J. Physiol. 270:L863-L871(1996).
CC   -!- FUNCTION: May associate with CD21. May regulate the release of Ca(2+)
CC       from intracellular stores (By similarity).
CC       {ECO:0000250|UniProtKB:P08133}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8967522}.
CC       Melanosome {ECO:0000250|UniProtKB:P08133,
CC       ECO:0000250|UniProtKB:P48037}. Note=Cytoplasmic in lung alveolar
CC       endothelial cells.
CC   -!- TISSUE SPECIFICITY: In the lung, expressed by alveolar endothelial
CC       cells. Not expressed in tracheal endothelium or alveolar macrophages.
CC       {ECO:0000269|PubMed:8967522}.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid. {ECO:0000250|UniProtKB:P08133}.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:8967522}.
CC   -!- MISCELLANEOUS: Seems to bind one calcium ion with high affinity.
CC       {ECO:0000250|UniProtKB:P08133}.
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245}.
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DR   PRIDE; Q9TS53; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.220.10; -; 1.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 1.
PE   1: Evidence at protein level;
KW   Annexin; Calcium; Calcium/phospholipid-binding; Cytoplasm;
KW   Direct protein sequencing; Reference proteome; Repeat.
FT   CHAIN           <1..>40
FT                   /note="Annexin A6"
FT                   /id="PRO_0000306196"
FT   REPEAT          <1..4
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000250|UniProtKB:P08133"
FT   REPEAT          <21..>40
FT                   /note="Annexin 6"
FT                   /evidence="ECO:0000250|UniProtKB:P08133"
FT   NON_CONS        20..21
FT                   /evidence="ECO:0000303|PubMed:8967522"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:8967522"
FT   NON_TER         40
FT                   /evidence="ECO:0000303|PubMed:8967522"
SQ   SEQUENCE   40 AA;  4376 MW;  C3771E8375C50856 CRC64;
     LVVLLQGTRE EDDVVREQLV EGAGTDEKAL IEILATRXNA