ID   HLY3_BACCE              Reviewed;         219 AA.
AC   P54176;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Hemolysin-3;
DE   AltName: Full=Hemolysin III;
DE            Short=Hly-III;
OS   Bacillus cereus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1396;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=VKM B-164;
RX   PubMed=7495855; DOI=10.1016/0167-4781(95)00150-f;
RA   Baida G.E., Kuzmin N.P.;
RT   "Cloning and primary structure of a new hemolysin gene from Bacillus
RT   cereus.";
RL   Biochim. Biophys. Acta 1264:151-154(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0073 (Hly-III) family. {ECO:0000305}.
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DR   EMBL; X84058; CAA58877.1; -; Genomic_DNA.
DR   PIR; S59967; S59967.
DR   RefSeq; WP_000136895.1; NZ_NVKE01000010.1.
DR   AlphaFoldDB; P54176; -.
DR   SMR; P54176; -.
DR   STRING; 1396.DJ87_2579; -.
DR   TCDB; 1.C.113.1.1; the hemolysin iii (hly iii) family.
DR   GeneID; 59157613; -.
DR   eggNOG; COG1272; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR005744; Hy-lIII.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   TIGRFAMs; TIGR01065; hlyIII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytolysis; Hemolysis; Membrane; Toxin; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..219
FT                   /note="Hemolysin-3"
FT                   /id="PRO_0000176895"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24407 MW;  E397FC88B05E37F7 CRC64;
     MTEKMTRMTQ FVKEEIANAI THGIGAILSI PALIILIIHA SKHGTASAVV AFTVYGVSMF
     LLYLFSTLLH SIHHPKVEKL FTILDHSAIY LLIAGTYTPF LLITLRGPLG WTLLAIIWTL
     AIGGIIFKIF FVRRFIKAST LCYIIMGWLI IVAIKPLYEN LTGHGFSLLL AGGILYSVGA
     IFFLWEKLPF NHAIWHLFVL GGSAMMFFCV LFYVLPTAS