ID   HLY4_AERSA              Reviewed;         578 AA.
AC   Q08677;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Hemolysin 4;
DE   Flags: Precursor;
GN   Name=ash4;
OS   Aeromonas salmonicida.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=645;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=17-2;
RX   PubMed=8309354; DOI=10.1006/mpat.1993.1077;
RA   Hirono I., Aoki T.;
RT   "Cloning and characterization of three hemolysin genes from Aeromonas
RT   salmonicida.";
RL   Microb. Pathog. 15:269-282(1993).
CC   -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC       membranes and cause cell rupture by mechanisms not clearly defined.
CC   -!- SIMILARITY: Belongs to the HlyA hemolysin family. {ECO:0000305}.
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DR   EMBL; X65049; CAA46185.1; -; Genomic_DNA.
DR   PIR; I39671; S26577.
DR   AlphaFoldDB; Q08677; -.
DR   SMR; Q08677; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   CDD; cd00161; RICIN; 1.
DR   Gene3D; 3.30.110.130; -; 1.
DR   InterPro; IPR022220; Hemolysin_N.
DR   InterPro; IPR043080; Hemolysin_N_sf.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR000772; Ricin_B_lectin.
DR   Pfam; PF12563; Hemolysin_N; 1.
DR   Pfam; PF07968; Leukocidin; 2.
DR   SMART; SM00458; RICIN; 1.
DR   SUPFAM; SSF50370; SSF50370; 1.
DR   PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Hemolysis; Lectin; Signal; Toxin; Virulence.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..578
FT                   /note="Hemolysin 4"
FT                   /id="PRO_0000013367"
FT   DOMAIN          448..539
FT                   /note="Ricin B-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00174"
FT   REGION          289..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  63401 MW;  B07DB1FA854B8E52 CRC64;
     MLASLQSEQG LVYLNASSWL DEQQAAKALT RDQLRERVLG QGERIFIDFS GITDKAEPEQ
     ARKAMEQLAG ISFDADWVLV SAYKGELLFT PLGPPDDPAF YQVMERIDTL AGQGKRHKRS
     LTQTATAEAG LPRGAFYLKL NRKISVAECT FPRSRTWDRG DRLFCDSPNI SLVYRVNLER
     SLQFGNTGSA TPDAKIVRIS LDDESAGGGI QLNEDLTWSE NIADYLLLDG WARDYATDAI
     AQDYRFTIDA SNTKAAVLKS LPTNLNSKYE HRRISGFEVG VTGGVEVNKD GPKASWRRRP
     SSASSVTMPT TPRIIGSNAR PECPEGEFQL GAGSIRDGGV TALLQDRHRL GNGVRCGSQP
     HPAAELQGLR AESGCHLQGG ADETGSTEFK IDSSVNIRPI YTGIYKHYYV VGGHVSFQGF
     EDVDKRRRVT ASTSFKVDWN HPVFTGGRPV NLQLGGFDNR CLSAGAEHGL SAVTCDETSA
     AQSFIYDQYG RYVSALDTRR CLDGNNLGQL QSCRLSLGQR WEWKADSDAL SNLSAHQLLG
     HNKQTGELAL YDENGNPADV SVRTLTSYTR ILRATAGN