ID   HLYA_AERHY              Reviewed;          85 AA.
AC   Q44066;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Putative membrane protein insertion efficiency factor {ECO:0000255|HAMAP-Rule:MF_00386};
DE   AltName: Full=Putative alpha-hemolysin;
GN   Name=hlyA;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ah20;
RA   Chen J.D., Lai S.Y., Chen C.H.;
RT   "Cloning, expression and sequencing of Aeromonas hydrophila alpha-hemolysin
RT   gene determinant.";
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be involved in insertion of integral membrane proteins
CC       into the membrane. {ECO:0000255|HAMAP-Rule:MF_00386}.
CC   -!- FUNCTION: Lyses fish blood cells. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00386};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00386};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00386}.
CC   -!- SIMILARITY: Belongs to the UPF0161 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00386}.
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DR   EMBL; L36462; AAB81225.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q44066; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   HAMAP; MF_00386; UPF0161_YidD; 1.
DR   InterPro; IPR002696; Membr_insert_effic_factor.
DR   PANTHER; PTHR33383; PTHR33383; 1.
DR   Pfam; PF01809; YidD; 1.
DR   SMART; SM01234; Haemolytic; 1.
DR   TIGRFAMs; TIGR00278; TIGR00278; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytolysis; Hemolysis; Membrane; Toxin; Virulence.
FT   CHAIN           1..85
FT                   /note="Putative membrane protein insertion efficiency
FT                   factor"
FT                   /id="PRO_0000171785"
SQ   SEQUENCE   85 AA;  9345 MW;  1FCEDA95833350C5 CRC64;
     MASALSPGSR VLIALIRVYQ RLISPLLGPH CRFTPTCSSY GIEALRRFGV IKGSWLTVKR
     VLKCHPLHPG GDDPVPPGPF DTREH