ID   HLYA_BRAHO              Reviewed;         240 AA.
AC   Q06803;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hemolysin A;
GN   Name=tlyA; Synonyms=tly;
OS   Brachyspira hyodysenteriae (Treponema hyodysenteriae).
OC   Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX   NCBI_TaxID=159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B204;
RX   PubMed=1730486; DOI=10.1128/iai.60.2.529-535.1992;
RA   Muir S., Koopman M.B.H., Libby S.J., Joens L.A., Heffron F., Kusters J.G.;
RT   "Cloning and expression of a Serpula (Treponema) hyodysenteriae hemolysin
RT   gene.";
RL   Infect. Immun. 60:529-535(1992).
CC   -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC       membranes and cause cell rupture by mechanisms not clearly defined.
CC   -!- INDUCTION: By sodium ribonucleate.
CC   -!- SIMILARITY: Belongs to the TlyA family. {ECO:0000305}.
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DR   EMBL; X61684; CAA43858.1; -; Genomic_DNA.
DR   PIR; A43863; A43863.
DR   RefSeq; WP_012669791.1; NZ_MKXF01000017.1.
DR   AlphaFoldDB; Q06803; -.
DR   SMR; Q06803; -.
DR   TCDB; 1.C.109.1.1; the bacterial hemolysin a (tlya) family.
DR   GeneID; 63961365; -.
DR   OMA; VLMVKPQ; -.
DR   BRENDA; 2.1.1.226; 6427.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:InterPro.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR004538; Haemolysin_A/TlyA.
DR   InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR32319:SF0; PTHR32319:SF0; 1.
DR   Pfam; PF01728; FtsJ; 1.
DR   Pfam; PF01479; S4; 1.
DR   PIRSF; PIRSF005578; TlyA; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00478; tly; 1.
DR   PROSITE; PS50889; S4; 1.
PE   2: Evidence at transcript level;
KW   Cytolysis; Hemolysis; RNA-binding; Toxin; Virulence.
FT   CHAIN           1..240
FT                   /note="Hemolysin A"
FT                   /id="PRO_0000083992"
FT   DOMAIN          1..61
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
SQ   SEQUENCE   240 AA;  26881 MW;  E718A0A21DF3CCB7 CRC64;
     MRLDEYVHSE GYTESRSKAQ DIILAGCVFV NGVKVTSKAH KIKDTDNIEV VQNIKYVSRA
     GEKLEKAFVE FGISVENKIC LDIGASTGGF TDCLLKHGAK KVYALDVGHN QLVYKLRNDN
     RVVSIEDFNA KDINKEMFND EIPSVIVSDV SFISITKIAP IIFKELNNLE FWVTLIKPQF
     EAERGDVSKG GIIRDDILRE KILNNAISKI IDCGFKEVNR TISPIKGAKG NIEYLAHFII