ID   HLYB_PROMI              Reviewed;         561 AA.
AC   P16465;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Hemolysin transporter protein HpmB;
DE   Flags: Precursor;
GN   Name=hpmB;
OS   Proteus mirabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=584;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 477-12;
RX   PubMed=2407716; DOI=10.1128/jb.172.3.1206-1216.1990;
RA   Uphoff T.S., Welch R.A.;
RT   "Nucleotide sequencing of the Proteus mirabilis calcium-independent
RT   hemolysin genes (hpmA and hpmB) reveals sequence similarity with the
RT   Serratia marcescens hemolysin genes (shlA and shlB).";
RL   J. Bacteriol. 172:1206-1216(1990).
CC   -!- FUNCTION: Interacts with the cell-bound hemolysin. Necessary for the
CC       extracellular secretion and activation of the hemolysin.
CC   -!- FUNCTION: Probable member of a two partner secretion pathway (TPS) in
CC       which it mediates the secretion of hemolysin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- DOMAIN: Probably a beta-barrel protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; M30186; AAA25656.1; -; Genomic_DNA.
DR   PIR; B35140; B35140.
DR   AlphaFoldDB; P16465; -.
DR   SMR; P16465; -.
DR   STRING; 584.AOUC001_04495; -.
DR   TCDB; 1.B.20.1.2; the two-partner secretion (tps) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   InterPro; IPR035251; ShlB_POTRA.
DR   InterPro; IPR027282; TPS.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF17287; POTRA_3; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PIRSF; PIRSF029745; FhaC; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Cytolysis; Hemolysis; Ion transport; Membrane; Porin;
KW   Protein transport; Signal; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..17
FT   CHAIN           18..561
FT                   /note="Hemolysin transporter protein HpmB"
FT                   /id="PRO_0000018664"
FT   DOMAIN          77..150
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   561 AA;  63222 MW;  6849E9C3BAA2891D CRC64;
     MKKKVVLLTL LSCFSTSGLS ANETGNLGSI SESRRALQDS QREINQLIEQ NRYQQLQEKA
     VNISPTPTLI TESEHCLPIK GVYIQGITLL TEKDLNSLSP LPDQCIKSAD INRLVKELTQ
     RYLQHGYITA RIQFLRPNQH GELGLYAIEG FVERIEGGDR GVNTTLLFPR IKGQPLKLAT
     LDQGLDQANR LQSNKVTVDI LPGTELGGSV IKLSNQRKSP WHLNIASDNY GQKNSGRWLI
     RTNASLDSPL GLSDFVSLNA NITTDNPNTR FNRAYTLLYS IPYGGFTFSS FGSYSEYQFH
     QKLQTRTVNL YGDTTQVGIR GDYAFSRSQK QIDTLNIQVT HKRIRNYFSQ IRLDLSSPKL
     TTIELGINHL QIIPNGVLST NLSVEKAVGW FGAEETPYIA NGNGNDYRFT KVKLFTNWYQ
     RFSLWHSTFL FNSTFLGQYS HDTLPGVEWL SLTDKNAIRG FDQSTLSGDN GGYLRNTLSY
     PYRLNHFSIT PRIGVDIGQV KQHGNYKGWQ GGYGLSSGLN IQYQQAQLDL EVAKGELLYH
     QTNSNKTKDP TQLLVKFSYL F