ID   HLYB_SERMA              Reviewed;         557 AA.
AC   P15321;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hemolysin transporter protein ShlB;
DE   Flags: Precursor;
GN   Name=shlB;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 19-24.
RC   STRAIN=K38, and SN8;
RX   PubMed=3290200; DOI=10.1128/jb.170.7.3177-3188.1988;
RA   Poole K., Schiebel E., Braun V.;
RT   "Molecular characterization of the hemolysin determinant of Serratia
RT   marcescens.";
RL   J. Bacteriol. 170:3177-3188(1988).
CC   -!- FUNCTION: Interacts with the cell-bound hemolysin. Necessary for the
CC       extracellular secretion and activation of hemolysin.
CC   -!- FUNCTION: Member of a two partner secretion pathway (TPS) in which it
CC       mediates the secretion of hemolysin.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- DOMAIN: Probably a beta-barrel protein. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPS (TC 1.B.20) family. {ECO:0000305}.
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DR   EMBL; M22618; AAA50322.1; -; Genomic_DNA.
DR   PIR; B28182; B28182.
DR   AlphaFoldDB; P15321; -.
DR   SMR; P15321; -.
DR   STRING; 273526.SMDB11_3736; -.
DR   TCDB; 1.B.20.1.1; the two-partner secretion (tps) family.
DR   PRIDE; P15321; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IMP:CACAO.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005565; Hemolysn_activator_HlyB_C.
DR   InterPro; IPR013686; Polypept-transport_assoc_ShlB.
DR   InterPro; IPR034746; POTRA.
DR   InterPro; IPR035251; ShlB_POTRA.
DR   InterPro; IPR027282; TPS.
DR   Pfam; PF08479; POTRA_2; 1.
DR   Pfam; PF17287; POTRA_3; 1.
DR   Pfam; PF03865; ShlB; 1.
DR   PIRSF; PIRSF029745; FhaC; 1.
DR   PROSITE; PS51779; POTRA; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Ion transport; Membrane; Porin; Protein transport; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:3290200"
FT   CHAIN           19..557
FT                   /note="Hemolysin transporter protein ShlB"
FT                   /id="PRO_0000018665"
FT   DOMAIN          79..152
FT                   /note="POTRA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   557 AA;  61917 MW;  033D777BBF5B14B1 CRC64;
     MIKKITALTL LVSTALSAET LPDSHMMQDM SMGESRRALQ DSTREVNQLI EQRRYQQLKQ
     QRLLAEPAAP ALPQSAQCLP IAGVYLQGVT LLSPADLSAL SGLPEQCISS NDINRLTREL
     TRLYVQKGYI TARVQIVRPN SQGELGLSVT EGFIEKIEGG DRWVNSRLLF PGLEGKPLKL
     TELDQGLDQA NRLQSNTTKL DILPGRQVGG SVIRLRNQHA KPWLITAGTD NYGQKSTGRW
     LARATATLDS PFGLSDFVSL NANSTLENPA HRYNRAYTLL YSLPYGAFTF SGFASFSSYE
     NHQQLPHNVV KLHGQTQQYG LRSDYVFYRD HDQIDSLSGQ LTYKRIDNYF ESVRLEVSSP
     TLTLAELSAS HLQILPNGVF SANLSVEQGM PWLGAGRHPS SVHLDSQFTK GKLFANLSQR
     LRLGDATYQL NNLFYGQYSR DPLPGVEWLS LTDRSAVRGF SRSTQSGDNG WYLQNTLSRS
     FNLGATTLTP RLGADVGRIL PRQDNSGWRS SAGISTGATL RYQRALVDLE VSRGWILSNH
     ATPEDPVQVL ARFSYTF