HLYC_BRAHO
ID HLYC_BRAHO Reviewed; 268 AA.
AC Q54318;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Hemolysin C;
GN Name=tlyC;
OS Brachyspira hyodysenteriae (Treponema hyodysenteriae).
OC Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX NCBI_TaxID=159;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B204;
RX PubMed=7968456; DOI=10.1006/mpat.1994.1028;
RA Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M.,
RA Gaastra W., Kusters J.G.;
RT "Characterization of three putative Serpulina hyodysenteriae hemolysins.";
RL Microb. Pathog. 16:269-282(1994).
CC -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC membranes and cause cell rupture by mechanisms not clearly defined.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X73141; CAA51657.1; -; Genomic_DNA.
DR PIR; T46749; T46749.
DR RefSeq; WP_012670944.1; NZ_MKXF01000005.1.
DR AlphaFoldDB; Q54318; -.
DR SMR; Q54318; -.
DR TCDB; 1.C.126.1.1; the hlyc haemolysin (hlyc) family.
DR GeneID; 63962524; -.
DR OMA; QMISIKA; -.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Cytolysis; Hemolysis; Repeat; Toxin; Virulence.
FT CHAIN 1..268
FT /note="Hemolysin C"
FT /id="PRO_0000088354"
FT DOMAIN 52..111
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 114..171
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ SEQUENCE 268 AA; 30764 MW; E56A3D43D8764FDA CRC64;
MPIKKLISKI VKKKDSDTEK NNYINLSALT EAEREIITNT IELKSKSVRE IMVPRVDVVM
IPMESSYDKV IKAFNRDRNS RIPVYKDGID DIVGVLYVKD LIDAEEKNFS LKKILHKPLF
VPISISLMEL LKNFREKQIH IAMVVDEYGG FSGIVSMEDV LEQIIGDIRD EYDEEDEEIK
SNDDGTYLVD ARTRIDDFNK YEILPPIPDD EADTVGGFLF SYLGRLPKRN EDIEYNGYSF
TVVGKSGNIV TKIRIEKLKK DNTAKNKD