ID   HLYC_BRAHO              Reviewed;         268 AA.
AC   Q54318;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Hemolysin C;
GN   Name=tlyC;
OS   Brachyspira hyodysenteriae (Treponema hyodysenteriae).
OC   Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira.
OX   NCBI_TaxID=159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B204;
RX   PubMed=7968456; DOI=10.1006/mpat.1994.1028;
RA   Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M.,
RA   Gaastra W., Kusters J.G.;
RT   "Characterization of three putative Serpulina hyodysenteriae hemolysins.";
RL   Microb. Pathog. 16:269-282(1994).
CC   -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC       membranes and cause cell rupture by mechanisms not clearly defined.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; X73141; CAA51657.1; -; Genomic_DNA.
DR   PIR; T46749; T46749.
DR   RefSeq; WP_012670944.1; NZ_MKXF01000005.1.
DR   AlphaFoldDB; Q54318; -.
DR   SMR; Q54318; -.
DR   TCDB; 1.C.126.1.1; the hlyc haemolysin (hlyc) family.
DR   GeneID; 63962524; -.
DR   OMA; QMISIKA; -.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Cytolysis; Hemolysis; Repeat; Toxin; Virulence.
FT   CHAIN           1..268
FT                   /note="Hemolysin C"
FT                   /id="PRO_0000088354"
FT   DOMAIN          52..111
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          114..171
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   268 AA;  30764 MW;  E56A3D43D8764FDA CRC64;
     MPIKKLISKI VKKKDSDTEK NNYINLSALT EAEREIITNT IELKSKSVRE IMVPRVDVVM
     IPMESSYDKV IKAFNRDRNS RIPVYKDGID DIVGVLYVKD LIDAEEKNFS LKKILHKPLF
     VPISISLMEL LKNFREKQIH IAMVVDEYGG FSGIVSMEDV LEQIIGDIRD EYDEEDEEIK
     SNDDGTYLVD ARTRIDDFNK YEILPPIPDD EADTVGGFLF SYLGRLPKRN EDIEYNGYSF
     TVVGKSGNIV TKIRIEKLKK DNTAKNKD