ID   ANXA7_DICDI             Reviewed;         462 AA.
AC   P24639; Q1ZXQ3; Q55DX5;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 143.
DE   RecName: Full=Annexin A7;
DE   AltName: Full=Annexin VII;
DE   AltName: Full=Annexin-7;
DE   AltName: Full=Synexin;
GN   Name=nxnA; Synonyms=ann7; ORFNames=DDB_G0269160;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG).
RC   STRAIN=AX2;
RX   PubMed=1826615; DOI=10.1016/0167-4781(91)90137-b;
RA   Greenwood M., Tsang A.;
RT   "Sequence and expression of annexin VII of Dictyostelium discoideum.";
RL   Biochim. Biophys. Acta 1088:429-432(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC   STRAIN=AX4;
RX   PubMed=1832674; DOI=10.1016/s0021-9258(19)47401-2;
RA   Doring V., Schleicher M., Noegel A.A.;
RT   "Dictyostelium annexin VII (synexin). cDNA sequence and isolation of a gene
RT   disruption mutant.";
RL   J. Biol. Chem. 266:17509-17515(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   PROTEIN SEQUENCE OF 143-437.
RX   PubMed=1824843; DOI=10.1016/s0021-9258(18)52351-6;
RA   Gerke V.;
RT   "Identification of a homologue for annexin VII (synexin) in Dictyostelium
RT   discoideum.";
RL   J. Biol. Chem. 266:1697-1700(1991).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 108-462.
RX   PubMed=9231902; DOI=10.1006/jmbi.1997.1091;
RA   Liemann S., Bringemeier I., Benz J., Goettig P., Hofmann A., Huber R.,
RA   Noegel A.A., Jacob U.;
RT   "Crystal structure of the C-terminal tetrad repeat from synexin (annexin
RT   VII) of Dictyostelium discoideum.";
RL   J. Mol. Biol. 270:79-88(1997).
CC   -!- FUNCTION: Calcium/phospholipid-binding protein which promotes membrane
CC       fusion and is involved in exocytosis.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P24639-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P24639-2; Sequence=VSP_000288;
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid.
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245, ECO:0000305}.
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DR   EMBL; X60269; CAA42815.1; -; Genomic_DNA.
DR   EMBL; X60270; CAA42815.1; JOINED; mRNA.
DR   EMBL; X60270; CAA42816.1; -; mRNA.
DR   EMBL; M69022; AAA33166.1; -; mRNA.
DR   EMBL; AAFI02000005; EAL71930.1; -; Genomic_DNA.
DR   EMBL; AAFI02000005; EAS66935.1; -; Genomic_DNA.
DR   PIR; S14723; LUDO7.
DR   RefSeq; XP_001134471.1; XM_001134471.1.
DR   RefSeq; XP_646006.1; XM_640914.1.
DR   AlphaFoldDB; P24639; -.
DR   SMR; P24639; -.
DR   STRING; 44689.DDB0232009; -.
DR   PaxDb; P24639; -.
DR   EnsemblProtists; EAL71930; EAL71930; DDB_G0269160.
DR   EnsemblProtists; EAS66935; EAS66935; DDB_G0269160.
DR   GeneID; 8616954; -.
DR   KEGG; ddi:DDB_G0269160; -.
DR   dictyBase; DDB_G0269160; nxnA.
DR   eggNOG; KOG0819; Eukaryota.
DR   HOGENOM; CLU_025300_6_2_1; -.
DR   InParanoid; P24639; -.
DR   OMA; RCTRNIR; -.
DR   PhylomeDB; P24639; -.
DR   Reactome; R-DDI-114608; Platelet degranulation.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:P24639; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0010008; C:endosome membrane; IDA:dictyBase.
DR   GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IDA:dictyBase.
DR   GO; GO:0001786; F:phosphatidylserine binding; IDA:dictyBase.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:dictyBase.
DR   GO; GO:0001778; P:plasma membrane repair; IMP:dictyBase.
DR   GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR   GO; GO:0009611; P:response to wounding; IMP:dictyBase.
DR   GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 2.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   1: Evidence at protein level;
KW   Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding;
KW   Direct protein sequencing; Reference proteome; Repeat.
FT   CHAIN           1..462
FT                   /note="Annexin A7"
FT                   /id="PRO_0000067502"
FT   REPEAT          161..232
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          233..304
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          315..388
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          392..462
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REGION          1..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7..131
FT                   /note="19 X 6 AA tandem repeats of Q-G-Y-P-P-Q"
FT   COMPBIAS        13..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..130
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         13..55
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:1832674"
FT                   /id="VSP_000288"
FT   CONFLICT        245
FT                   /note="A -> R (in Ref. 2; AAA33166)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   462 AA;  51172 MW;  6C846EE480A69AF9 CRC64;
     MSYPPNQGYP PQSNSPQPGQ YGAPQQGYPP QQGYPPQQGY PPQQGYPPQQ GYPPQQGYPP
     QQGYPPQQGY PPQQGYPPQQ GYPPQQGYPP QQGYPPQQGY PPQQGYPPQQ GYPPQQGYPP
     QGYPPQQGYP PVGVPVGVPV GFAPGMVVGY HQGYFVGTIT HDCKHDAEVL RKAMKGIGTN
     ESDLIKVLAN RNWAEREQIK REFSAKYSKD LIQDIKSETS GNFEKCLVAL LTEPAHFDVE
     QIHSACAGAG TNENTIIEIL VTRSNVQMEY IKQIFKNKHG KSLKDRLESE ASGDFKKLLE
     KLTEPRDESP VINPMQVSKD AEDLYKAGEG KIGTDEKEFI KILTSRSLPH IAAVASEYIK
     HHKKHSLIKA IDSEFSGSIK TGLIAIVTYA LNPYGYFAEI LNKSMKGAGT NDNKLIRTVV
     TQMHNMPQIK TAYSTLFKNS LAHDIQADCS GDFKKLLLDI IS