ID   HLYC_RICCN              Reviewed;         299 AA.
AC   Q92GI2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Hemolysin C homolog;
GN   Name=tlyC; OrderedLocusNames=RC1141;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- MISCELLANEOUS: Despite the presence of the tlyC gene, the true SFG
CC       rickettsiae are non-hemolytic.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. Hemolysin C subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006914; AAL03679.1; -; Genomic_DNA.
DR   PIR; E97842; E97842.
DR   RefSeq; WP_010977712.1; NC_003103.1.
DR   AlphaFoldDB; Q92GI2; -.
DR   SMR; Q92GI2; -.
DR   EnsemblBacteria; AAL03679; AAL03679; RC1141.
DR   KEGG; rco:RC1141; -.
DR   PATRIC; fig|272944.4.peg.1315; -.
DR   HOGENOM; CLU_015237_3_1_5; -.
DR   OMA; ERRHMAL; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Repeat.
FT   CHAIN           1..299
FT                   /note="Hemolysin C homolog"
FT                   /id="PRO_0000319030"
FT   DOMAIN          80..142
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          145..202
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   299 AA;  33924 MW;  068DA787C61C5FF4 CRC64;
     MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL KINSQKMTLD
     ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE SIKLEVPHTR TLIYDGTLDN
     VVGFIHIKDL FKALATKQNG RLKKLIRKHI IAAPSMKLLD LLAKMRRERT HIAIVVDEYG
     GTDGLVTIED LIEEIVGRID DEHDQQLDSD NFKVINNSTI IANARVEVEV LEEIIGEKLH
     NDYDEFDTIG GLVLTRVSSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNGQ