ID   HLYC_RICM5              Reviewed;         299 AA.
AC   A8F2M1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Hemolysin C homolog;
GN   Name=tlyC; OrderedLocusNames=RMA_1168;
OS   Rickettsia massiliae (strain Mtu5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=416276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mtu5;
RX   PubMed=17916642; DOI=10.1101/gr.6742107;
RA   Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.;
RT   "Lateral gene transfer between obligate intracellular bacteria: evidence
RT   from the Rickettsia massiliae genome.";
RL   Genome Res. 17:1657-1664(2007).
CC   -!- MISCELLANEOUS: Despite the presence of the tlyC gene, the true SFG
CC       rickettsiae are non-hemolytic.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. Hemolysin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABV85157.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000683; ABV85157.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014365448.1; NC_009900.1.
DR   AlphaFoldDB; A8F2M1; -.
DR   SMR; A8F2M1; -.
DR   EnsemblBacteria; ABV85157; ABV85157; RMA_1168.
DR   KEGG; rms:RMA_1168; -.
DR   HOGENOM; CLU_015237_3_1_5; -.
DR   Proteomes; UP000001311; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Repeat.
FT   CHAIN           1..299
FT                   /note="Hemolysin C homolog"
FT                   /id="PRO_0000319032"
FT   DOMAIN          80..142
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          145..202
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   299 AA;  33931 MW;  50AC4E3FB832DD22 CRC64;
     MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL KINSQKMTLD
     ERNILANLLE LEYKTIEDIM VPRSDIAAIK LTTNLEELSE SIKLEVPHTR TLIYDGTLDN
     VVGFIHIKDL FKALATKQNG RLKKLIRKHI IAAPSMKLLD LLAKMRRERT HIAIVVDEYG
     GTDGLVTIED LIEEIVGRID DEHDQQLDSD NFKVINNSTI ISNARVEVEV LEEIIGEKLQ
     NDDDEFDTIG GLVLTRVSSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNGK