HLYC_RICTY
ID HLYC_RICTY Reviewed; 305 AA.
AC Q68W10; O87917;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Hemolysin C;
GN Name=tlyC; OrderedLocusNames=RT0725;
OS Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=257363;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN HEMOLYSIS.
RC STRAIN=ATCC VR-144 / Wilmington;
RX PubMed=10531273; DOI=10.1128/iai.67.11.6104-6108.1999;
RA Radulovic S., Troyer J.M., Beier M.S., Lau A.O.T., Azad A.F.;
RT "Identification and molecular analysis of the gene encoding Rickettsia
RT typhi hemolysin.";
RL Infect. Immun. 67:6104-6108(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-144 / Wilmington;
RX PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA Yu X.-J., Walker D.H., Weinstock G.M.;
RT "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT of other Rickettsiae.";
RL J. Bacteriol. 186:5842-5855(2004).
CC -!- MISCELLANEOUS: Confers a hemolytic phenotype when expressed in the
CC nonhemolytic mutant of Proteus mirabilis.
CC -!- SIMILARITY: Belongs to the UPF0053 family. Hemolysin C subfamily.
CC {ECO:0000305}.
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DR EMBL; U97482; AAC62436.1; -; Genomic_DNA.
DR EMBL; AE017197; AAU04182.1; -; Genomic_DNA.
DR RefSeq; WP_011191158.1; NC_006142.1.
DR AlphaFoldDB; Q68W10; -.
DR SMR; Q68W10; -.
DR STRING; 257363.RT0725; -.
DR EnsemblBacteria; AAU04182; AAU04182; RT0725.
DR KEGG; rty:RT0725; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_015237_3_1_5; -.
DR OMA; ERRHMAL; -.
DR OrthoDB; 1155802at2; -.
DR Proteomes; UP000000604; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
PE 1: Evidence at protein level;
KW CBS domain; Cytolysis; Hemolysis; Repeat; Toxin; Virulence.
FT CHAIN 1..305
FT /note="Hemolysin C"
FT /id="PRO_0000319034"
FT DOMAIN 81..142
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 146..203
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT CONFLICT 7
FT /note="K -> H (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 17
FT /note="D -> N (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="L -> F (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 56
FT /note="K -> Q (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="N -> D (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="A -> E (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="T -> P (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="K -> G (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 279
FT /note="I -> T (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
FT CONFLICT 299..302
FT /note="RDSF -> SD (in Ref. 1; AAC62436)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34629 MW; D2760B09AEE6F1EA CRC64;
MLKSSKKEDS SSKKNQDNKL IFIVRQLFYL IKHLFSKTKT PDNFFGIIKR LKINSKKMSL
DECNILANLL QLENKTVEDI MVPRSDIVAI KLTTNLAELS ESIKIEVPHT RTLIYDGTLD
NVVGFIHIKD LFKALATKQN STLKRLIRKH IIAAPSMKLL DLLAKMRRER THIAIVVDEY
GGTDGLVTIE DLIEEIVGRI DDEHDQQLDS TNFKVINNST IIANARIEVE LLEEIIKEKI
KNDDDEFDTI GGLVLTRVSS VPAIGTRIDI SENIEIEVID ATPRSLKQVK IRLKNGLNRD
SFNLT
