ID   HLYD_PASSP              Reviewed;         478 AA.
AC   P55125;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Leukotoxin secretion protein D;
GN   Name=lktD;
OS   Pasteurella haemolytica-like sp. (strain 5943B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Mannheimia.
OX   NCBI_TaxID=53500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8478098; DOI=10.1128/iai.61.5.2089-2095.1993;
RA   Chang Y.-F., Ma D.-P., Shi J., Chengappa M.M.;
RT   "Molecular characterization of a leukotoxin gene from a Pasteurella
RT   haemolytica-like organism, encoding a new member of the RTX toxin family.";
RL   Infect. Immun. 61:2089-2095(1993).
CC   -!- FUNCTION: Involved in the transport of the Leukotoxin.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; L12148; AAA16446.1; -; Genomic_DNA.
DR   AlphaFoldDB; P55125; -.
DR   SMR; P55125; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR006144; Secretion_HlyD_CS.
DR   InterPro; IPR010129; T1SS_HlyD.
DR   TIGRFAMs; TIGR01843; type_I_hlyD; 1.
DR   PROSITE; PS00543; HLYD_FAMILY; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytolysis; Hemolysis; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..478
FT                   /note="Leukotoxin secretion protein D"
FT                   /id="PRO_0000201877"
FT   TOPO_DOM        1..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..478
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   478 AA;  54650 MW;  221461A69482913A CRC64;
     MKIWLSGIYE FFLRYKNIWV EVWKIRKELD HPNRKKDESE FLPAHLELIE TPVSKKPRLI
     AYLIMLFLAV AIVLASVSKV EIVATAPGKL TFSGRSKEIK PIENTIVQEI FVKDGQFVEK
     GQLLVSLTAL GSDADIKKTI TSLSLAKLEN YRYQTLLTAI EKESLPVIDL SNTEFKDSSE
     EDRLRIKHLI EEQYTTWQKQ KTQKTLAYKR KDAEKQTISA YVRKYEGATR IEQEKLKDFR
     KLYQQKSLSK HELLSQENKA IEAQNELAVY RSKLNELESD LLNVKEELEL ITQFFKSDVL
     EKLKQHIENE RQLQLELEKN NQRRQASMIR APVSGTVQQL KIHTIGGVVT TAETLMIIVP
     EDDVLEATAL IQNKDIGFVA AGQEVIIKVE TFPYTRYGYI TGRIKHISPD AIEQPNLGLV
     FNATVSIDKQ ALSSPDGHKI ELGLGMTITA EIKTGERSVM SYLLSPLEES VTESLRER