ID   HLYEL_SHIFL             Reviewed;         113 AA.
AC   Q9RCT3; Q9RMG1;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Putative hemolysin E-like protein;
GN   OrderedLocusNames=SF1171, S1259;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 12022 / CDC 3591-52 / Serotype 2b;
RX   PubMed=10660049; DOI=10.1016/s0092-8674(00)81564-0;
RA   Wallace A.J., Stillman T.J., Atkins A., Jamieson S.J., Bullough P.A.,
RA   Green J., Artymiuk P.J.;
RT   "E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the
RT   toxin and observation of membrane pores by electron microscopy.";
RL   Cell 100:265-276(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CECT 585 / Serotype 2a;
RX   PubMed=10865950; DOI=10.1016/s0923-2508(00)00143-1;
RA   del Castillo F.J., Moreno F., del Castillo I.;
RT   "Characterization of the genes encoding the SheA haemolysin in Escherichia
RT   coli O157:H7 and Shigella flexneri 2a.";
RL   Res. Microbiol. 151:229-230(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- SIMILARITY: Belongs to the hemolysin E family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. Although it is strongly
CC       related to the hemolysin E toxin from E.coli K12 strain, it lacks all
CC       the C-terminal part of the protein, due to a deletion that creates a
CC       frameshift, and it is therefore not functional. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB65415.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF200955; AAF13995.1; -; Genomic_DNA.
DR   EMBL; AJ238955; CAB65415.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE005674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE014073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q9RCT3; -.
DR   SMR; Q9RCT3; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:InterPro.
DR   InterPro; IPR027018; Hemolysin_E.
DR   Pfam; PF06109; HlyE; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..113
FT                   /note="Putative hemolysin E-like protein"
FT                   /id="PRO_0000083994"
SQ   SEQUENCE   113 AA;  12880 MW;  C328908D14C5C4EB CRC64;
     MTEIVADKTV EVVKNAIETA DGALDLYNKY LDQVIPWQTF DETIKELSRF KQEYSQAASV
     LVGDIKTLLM DSQDKYFEAT QTVYEWCGVA TQLLAAYILL FDEYNEKKAS APH