ID   HLYS_HYDVU              Reviewed;         244 AA.
AC   Q52SK7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Hydralysin;
GN   Name=Hln {ECO:0000303|PubMed:15824108};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAX89442.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-105 AND ALA-211.
RX   PubMed=15824108; DOI=10.1074/jbc.m503242200;
RA   Sher D., Fishman Y., Zhang M., Lebendiker M., Gaathon A., Mancheno J.-M.,
RA   Zlotkin E.;
RT   "Hydralysins, a new category of beta-pore-forming toxins in cnidaria.";
RL   J. Biol. Chem. 280:22847-22855(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86LR2}.
CC   -!- SIMILARITY: Belongs to the hydralysin family. {ECO:0000305}.
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DR   EMBL; AY967764; AAX89442.1; -; mRNA.
DR   AlphaFoldDB; Q52SK7; -.
DR   SMR; Q52SK7; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Toxin.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..244
FT                   /note="Hydralysin"
FT                   /id="PRO_0000221561"
FT   VARIANT         105
FT                   /note="N -> S"
FT                   /evidence="ECO:0000269|PubMed:15824108"
FT   VARIANT         211
FT                   /note="T -> A"
FT                   /evidence="ECO:0000269|PubMed:15824108"
SQ   SEQUENCE   244 AA;  26128 MW;  5F1C23DAFA145231 CRC64;
     MGKELLTFSD LSWLDSSPDS VRKAFTNSYG RTPDGISVNN ETYFNAVKPA ITEQYGHYCY
     KRTGQTKIVS QQLSDPTDAV LGSSIARNRG DSPVTLTVSV AGTWNDSTSW STSAEAGVTM
     KSEFEVSGFF KTGAEFSVSV TAGKSGSSSV EKSSTSQIQV TVPPRSKVTV NMVGIMKKEK
     VCFEVPITVD GSFGANFGSS VQGHYFWFMS TDQALSKTSG IIKGTIDHAS VFDVSTEIGP
     SEPL