ID   ANXA7_MACFA             Reviewed;         488 AA.
AC   Q4R5L5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Annexin A7;
DE   AltName: Full=Annexin VII;
DE   AltName: Full=Annexin-7;
GN   Name=ANXA7; ORFNames=QccE-14346;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium/phospholipid-binding protein which promotes membrane
CC       fusion and is involved in exocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PDCD6. {ECO:0000250}.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for calcium
CC       and phospholipid. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01245, ECO:0000305}.
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DR   EMBL; AB169528; BAE01610.1; -; mRNA.
DR   RefSeq; NP_001271996.1; NM_001285067.1.
DR   AlphaFoldDB; Q4R5L5; -.
DR   SMR; Q4R5L5; -.
DR   STRING; 9541.XP_005565565.1; -.
DR   GeneID; 101925076; -.
DR   CTD; 310; -.
DR   eggNOG; KOG0819; Eukaryota.
DR   OrthoDB; 856254at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR018252; Annexin_repeat_CS.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   SMART; SM00335; ANX; 4.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS00223; ANNEXIN_1; 4.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Annexin; Calcium; Calcium/phospholipid-binding;
KW   Reference proteome; Repeat.
FT   CHAIN           1..488
FT                   /note="Annexin A7"
FT                   /id="PRO_0000236215"
FT   REPEAT          185..256
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          257..328
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          340..412
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          416..487
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REGION          1..143
FT                   /note="Repeat-rich region"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5..20
FT                   /note="3 X 5 AA tandem repeats of G-Y-P-P-X"
FT   REGION          71..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..92
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         233
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P20073"
SQ   SEQUENCE   488 AA;  52725 MW;  64206D6C4745D29B CRC64;
     MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP SSGYPGAGGY
     PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA GFSGYPQPPS QSYGGGPAQV
     PLPGGFPGGQ MPSQYPGGQP TYPSQINTES FPSYPVFSPV SLDYSSEPAA MTQGTQGTIR
     PAANFDAMRD AEILRKAMKG FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK
     SELSGNMEEL ILALFMPPTY YDAWTLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ
     SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSVNHQ MAQEDAQRLY QAGEGRLGTD
     ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS GYVESGLKTI LQCALNRPAF
     FAERLYYAMK GAGTDDSTLV RIVVTRSEID LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR
     PLLAIVGQ