ID   HLY_VIBMI               Reviewed;         189 AA.
AC   P28030;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Thermostable direct hemolysin;
DE   Flags: Precursor;
GN   Name=tdh;
OS   Vibrio mimicus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=674;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1650342; DOI=10.1128/jb.173.16.5036-5046.1991;
RA   Terai A., Baba K., Shirai H., Yoshida O., Takeda Y., Nishibuchi M.;
RT   "Evidence for insertion sequence-mediated spread of the thermostable direct
RT   hemolysin gene among Vibrio species.";
RL   J. Bacteriol. 173:5036-5046(1991).
CC   -!- FUNCTION: Bacterial hemolysins are exotoxins that attack blood cell
CC       membranes and cause cell rupture by mechanisms not clearly defined.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the TDH hemolysin family. {ECO:0000305}.
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DR   EMBL; M64120; AAA27571.1; -; Genomic_DNA.
DR   AlphaFoldDB; P28030; -.
DR   SMR; P28030; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.270.30; -; 1.
DR   InterPro; IPR038689; TDH_sf.
DR   InterPro; IPR005015; Thermostable_hemolysn_vibrio.
DR   Pfam; PF03347; TDH; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Disulfide bond; Hemolysis; Signal; Toxin; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..189
FT                   /note="Thermostable direct hemolysin"
FT                   /id="PRO_0000013364"
FT   DISULFID        175..185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21513 MW;  5B96108907AE5D38 CRC64;
     MKYQYFAKKS FLFISMLAAF KTFAFELPSV PFPAPGSDEI LFVVRDTTFN TKAPVNVKVS
     DFWTNRDVKR KPYEDVYGQS VFTTSGTKWL TSYMTVNIND KDYTMAAVSG YKSGHSAVFV
     KSDQVQLQHS YNSVANFVGE DEDSIPSKMY LDETPEYFVN VEAYESGSGN VLVMCISNKE
     SFFECEHQR