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HM02_CAEEL
ID   HM02_CAEEL              Reviewed;         209 AA.
AC   G5ECT8;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Homeobox protein ceh-2 {ECO:0000312|WormBase:C27A12.5};
GN   Name=ceh-2 {ECO:0000312|WormBase:C27A12.5};
GN   ORFNames=C27A12.5 {ECO:0000312|WormBase:C27A12.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|EMBL:AAO91835.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo {ECO:0000303|PubMed:12810585};
RX   PubMed=12810585; DOI=10.1242/dev.00551;
RA   Aspock G., Ruvkun G., Burglin T.R.;
RT   "The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for
RT   M3 pharynx motoneuron function.";
RL   Development 130:3369-3378(2003).
RN   [2] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for activity of the M3 pharyngeal motor neuron.
CC       {ECO:0000269|PubMed:12810585}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682,
CC       ECO:0000269|PubMed:12810585}.
CC   -!- TISSUE SPECIFICITY: In the anterior pharynx, expressed in the I3
CC       interneuron, the NSM and M3 motor neuron pairs, the three m2 muscle
CC       cells and the three e2 epithelial cells (at protein level).
CC       {ECO:0000269|PubMed:12810585}.
CC   -!- DEVELOPMENTAL STAGE: Earliest expression is detected in late
CC       gastrulation (at protein level). Expression is strongest in elongated
CC       embryos and early larvae. {ECO:0000269|PubMed:12810585}.
CC   -!- DISRUPTION PHENOTYPE: Mutants lacking the homeobox domain are viable
CC       and fertile but proliferate slightly more slowly than wild-type due to
CC       retarded larval development and reduced brood size. About 20% appear
CC       starved as they are shorter, thinner and paler at all stages with
CC       severely affected adults bearing only a few eggs. M3 neuron activity is
CC       decreased. {ECO:0000269|PubMed:12810585}.
CC   -!- MISCELLANEOUS: Can substitute for ems in D.melanogaster ems mutants,
CC       partially rescuing the mutant phenotype. {ECO:0000269|PubMed:12810585}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000255}.
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DR   EMBL; AY246428; AAO91835.1; -; mRNA.
DR   EMBL; AY246429; AAO91836.1; -; mRNA.
DR   EMBL; FO080101; CCD61202.1; -; Genomic_DNA.
DR   PIR; E87793; E87793.
DR   PIR; S05703; S05703.
DR   RefSeq; NP_491746.1; NM_059345.4.
DR   AlphaFoldDB; G5ECT8; -.
DR   SMR; G5ECT8; -.
DR   BioGRID; 56117; 2.
DR   IntAct; G5ECT8; 2.
DR   STRING; 6239.C27A12.5; -.
DR   PaxDb; G5ECT8; -.
DR   PeptideAtlas; G5ECT8; -.
DR   EnsemblMetazoa; C27A12.5.1; C27A12.5.1; WBGene00000429.
DR   GeneID; 191615; -.
DR   KEGG; cel:CELE_C27A12.5; -.
DR   CTD; 191615; -.
DR   WormBase; C27A12.5; CE20530; WBGene00000429; ceh-2.
DR   eggNOG; KOG0843; Eukaryota.
DR   GeneTree; ENSGT00940000169446; -.
DR   HOGENOM; CLU_1327426_0_0_1; -.
DR   InParanoid; G5ECT8; -.
DR   OMA; HVQMACS; -.
DR   OrthoDB; 1189098at2759; -.
DR   PhylomeDB; G5ECT8; -.
DR   PRO; PR:G5ECT8; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000429; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..209
FT                   /note="Homeobox protein ceh-2"
FT                   /id="PRO_0000430930"
FT   DNA_BIND        126..185
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   209 AA;  23414 MW;  3EE28E1C272B2F6D CRC64;
     MTLKFSVERL VDSEKESEEA DVEEQNNLKK LEEDEEDDEL CEKSGKNEPL SQTLSYFDVL
     LPHVQMACSN PFISGIGASG SGDQNLNTGA GGSVWQHPWL ELLQSTTAAQ FGDVTAGLFL
     QPLRKNKRIR TAFSASQLIQ LEKAFEGNHY VVGNERKQLA AKLSLTETQV KVWFQNRRTK
     HKRVRLEGSD PNAPMSNDED DEDDKKSVS
 
 
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