HM05_CAEEL
ID HM05_CAEEL Reviewed; 134 AA.
AC P20269; O17588;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 4.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Homeobox protein ceh-5;
GN Name=ceh-5; ORFNames=C16C2.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-94.
RC STRAIN=Bristol N2;
RX PubMed=2571091; DOI=10.1038/341239a0;
RA Buerglin T.R., Finney M., Coulson A., Ruvkun G.;
RT "Caenorhabditis elegans has scores of homoeobox-containing genes.";
RL Nature 341:239-243(1989).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; Z81036; CAB02740.2; -; Genomic_DNA.
DR PIR; S05706; S05706.
DR PIR; T19335; T19335.
DR RefSeq; NP_492586.2; NM_060185.4.
DR AlphaFoldDB; P20269; -.
DR SMR; P20269; -.
DR STRING; 6239.C16C2.1; -.
DR PaxDb; P20269; -.
DR EnsemblMetazoa; C16C2.1.1; C16C2.1.1; WBGene00000430.
DR GeneID; 191616; -.
DR KEGG; cel:CELE_C16C2.1; -.
DR UCSC; C16C2.1; c. elegans.
DR CTD; 191616; -.
DR WormBase; C16C2.1; CE40300; WBGene00000430; ceh-5.
DR eggNOG; KOG0843; Eukaryota.
DR GeneTree; ENSGT00940000154361; -.
DR HOGENOM; CLU_157463_0_0_1; -.
DR InParanoid; P20269; -.
DR OMA; RTLQFPM; -.
DR OrthoDB; 1534787at2759; -.
DR PhylomeDB; P20269; -.
DR PRO; PR:P20269; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000430; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..134
FT /note="Homeobox protein ceh-5"
FT /id="PRO_0000048982"
FT DNA_BIND 35..94
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 41..42
FT /note="VF -> DN (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 15417 MW; 73ABD2944F53C5E5 CRC64;
MPSADTEFIR VIRIKSANGS EKMLEIPAKL DLERPKRPRT VFTDEQLEKL EESFNTSGYL
SGSTRAKLAE SLGLSDNQVK VWFQNRRTKQ KKIDSRDPIK PETLKPAENY QNVYQNYQNY
WTAAAFLSNN VISS
