HM06_CAEEL
ID HM06_CAEEL Reviewed; 380 AA.
AC P20268; Q9GSZ8;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Homeobox protein ceh-6;
GN Name=ceh-6 {ECO:0000312|WormBase:K02B12.1};
GN ORFNames=K02B12.1 {ECO:0000312|WormBase:K02B12.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Bristol N2; TISSUE=Embryo;
RX PubMed=11171402; DOI=10.1242/dev.128.5.779;
RA Buerglin T.R., Ruvkun G.;
RT "Regulation of ectodermal and excretory function by the C. elegans POU
RT homeobox gene ceh-6.";
RL Development 128:779-790(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 182-340.
RC STRAIN=Bristol N2;
RX PubMed=2571091; DOI=10.1038/341239a0;
RA Buerglin T.R., Finney M., Coulson A., Ruvkun G.;
RT "Caenorhabditis elegans has scores of homoeobox-containing genes.";
RL Nature 341:239-243(1989).
RN [4]
RP FUNCTION, INTERACTION WITH EGL-27; SOX-2 AND SEM-4, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=22493276; DOI=10.1073/pnas.1117031109;
RA Kagias K., Ahier A., Fischer N., Jarriault S.;
RT "Members of the NODE (Nanog and Oct4-associated deacetylase) complex and
RT SOX-2 promote the initiation of a natural cellular reprogramming event in
RT vivo.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:6596-6601(2012).
RN [5]
RP INTERACTION WITH WDR-5.1.
RX PubMed=25124442; DOI=10.1126/science.1255885;
RA Zuryn S., Ahier A., Portoso M., White E.R., Morin M.C., Margueron R.,
RA Jarriault S.;
RT "Sequential histone-modifying activities determine the robustness of
RT transdifferentiation.";
RL Science 345:826-829(2014).
CC -!- FUNCTION: Vital for embryonic development and essential for the proper
CC function of the excretory cell (PubMed:11171402). Required for the
CC transdifferentiation of the Y rectal epithelial cell to the PDA motor
CC neuron during larval development (PubMed:22493276).
CC {ECO:0000269|PubMed:11171402, ECO:0000269|PubMed:22493276}.
CC -!- SUBUNIT: Interacts with egl-27, sox-2 and sem-4 (PubMed:22493276).
CC Interacts with wdr-5.1 (PubMed:25124442). {ECO:0000269|PubMed:22493276,
CC ECO:0000269|PubMed:25124442}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in a series of neurons in the ring
CC ganglia, excretory cell, dividing neuroblasts in the ventral cord and
CC rectal cells.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defective PDA
CC motor neuron differentiation as a result of failed Y rectal cell
CC migration from the rectum. {ECO:0000269|PubMed:22493276}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
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DR EMBL; AF286377; AAG10298.1; -; mRNA.
DR EMBL; BX284601; CAB00031.2; -; Genomic_DNA.
DR PIR; S05707; S05707.
DR PIR; T23218; T23218.
DR RefSeq; NP_492304.1; NM_059903.5.
DR AlphaFoldDB; P20268; -.
DR SMR; P20268; -.
DR BioGRID; 38073; 7.
DR DIP; DIP-61430N; -.
DR IntAct; P20268; 5.
DR STRING; 6239.K02B12.1; -.
DR PaxDb; P20268; -.
DR EnsemblMetazoa; K02B12.1.1; K02B12.1.1; WBGene00000431.
DR GeneID; 172640; -.
DR KEGG; cel:CELE_K02B12.1; -.
DR UCSC; K02B12.1; c. elegans.
DR CTD; 172640; -.
DR WormBase; K02B12.1; CE28045; WBGene00000431; ceh-6.
DR eggNOG; KOG3802; Eukaryota.
DR HOGENOM; CLU_013065_1_1_1; -.
DR InParanoid; P20268; -.
DR OMA; TQVIKPT; -.
DR OrthoDB; 1052276at2759; -.
DR PhylomeDB; P20268; -.
DR PRO; PR:P20268; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000431; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005829; C:cytosol; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:WormBase.
DR GO; GO:0060290; P:transdifferentiation; IMP:WormBase.
DR GO; GO:0030104; P:water homeostasis; IMP:WormBase.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Reference proteome.
FT CHAIN 1..380
FT /note="Homeobox protein ceh-6"
FT /id="PRO_0000100781"
FT DOMAIN 187..261
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 281..340
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42575 MW; 46890A452DF90A5E CRC64;
MLIPSSSSIP SSLSASASDS EPSSLNGSGI SDQNILPNYH LHHHLINENE MEAANYAQVI
KPTCEAFQDW PHTPMLYQQP QLHFMLPQHD WAYPHLAQSL PPPHHLTPST AAVAAATIAS
QSSIINQTSV VTSTPSCQIK QEVERPEIIQ RLMPPWPPAY QFSCDDSGSV SGAGGPHQPL
SDISDDSEQT CPDDLEGFAK QFKQRRIKLG YTQADVGVAL GTLYGNIFSQ TTICRFEALQ
LSFKNMCKLK PLLFKWLEEA DSTTGSPNST FEKMTGQAGR KRKKRTSIEV NVKSRLEFHF
QSNQKPNAQE ITQVAMELQL EKEVVRVWFC NRRQKEKRIA PNQYDAPHPM ALNNGYPMTA
DLFPYQAVVN HYTQQSPRQQ
