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HM08_CAEEL
ID   HM08_CAEEL              Reviewed;         276 AA.
AC   Q94398;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 3.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Homeobox protein ceh-8;
GN   Name=ceh-8 {ECO:0000312|WormBase:ZK265.4a};
GN   ORFNames=ZK265.4 {ECO:0000312|WormBase:ZK265.4a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; Z81143; CAB03519.2; -; Genomic_DNA.
DR   PIR; T27812; T27812.
DR   RefSeq; NP_492246.2; NM_059845.2.
DR   AlphaFoldDB; Q94398; -.
DR   SMR; Q94398; -.
DR   BioGRID; 56119; 10.
DR   IntAct; Q94398; 2.
DR   STRING; 6239.ZK265.4; -.
DR   EPD; Q94398; -.
DR   PaxDb; Q94398; -.
DR   EnsemblMetazoa; ZK265.4a.1; ZK265.4a.1; WBGene00000433.
DR   GeneID; 191617; -.
DR   KEGG; cel:CELE_ZK265.4; -.
DR   UCSC; ZK265.4; c. elegans.
DR   CTD; 191617; -.
DR   WormBase; ZK265.4a; CE38130; WBGene00000433; ceh-8.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000167708; -.
DR   HOGENOM; CLU_963860_0_0_1; -.
DR   InParanoid; Q94398; -.
DR   OMA; PYPIHFE; -.
DR   OrthoDB; 1085093at2759; -.
DR   PhylomeDB; Q94398; -.
DR   SignaLink; Q94398; -.
DR   PRO; PR:Q94398; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000433; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q94398; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISS:WormBase.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007389; P:pattern specification process; TAS:WormBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR032967; Rx-like.
DR   PANTHER; PTHR24329:SF405; PTHR24329:SF405; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Homeobox protein ceh-8"
FT                   /id="PRO_0000048984"
FT   DNA_BIND        60..119
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          28..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  31582 MW;  52A435990CEB2D25 CRC64;
     MSNPTDNNSA TSSITPNFSA FSSFTTYKPS DSFSSFESDS SPSKSSSSRK NRDKIADKKQ
     RRNRTTFTTF QLHALEAAFD KTHYPDVYAR ETLAAKVQLP EVRVQVWFQN RRAKFRRQEK
     QDCQGEEKHS LKDTMPSWSW MSENKTDTPP MLPPANTLSS THNNGISDEF FKTSEGKEVY
     GFPFAEYGTP ADNTHVSKTG NVFHLNFEDS DKKSMKKESP QTPSTSSPFI SEYHPPFIPY
     YIPNQSFSNA FNQYPMPFPY PIHFEPPQLT HSQENC
 
 
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